Dynamic laboratory X-ray phase-contrast microtomography with structure-based prior regularisation
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| Main Authors: | , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866915677140418560 |
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| author | Allan, Harry Partridge, Tom Jacob, Joseph Endrizzi, Marco |
| author_facet | Allan, Harry Partridge, Tom Jacob, Joseph Endrizzi, Marco |
| contents | X-ray microtomography is a versatile tool allowing the measurement of the 3D structure of optically thick samples. As a non-destructive technique, it is readily adapted to 4D imaging, where a sample can be monitored over time, and especially in conjunction with the application of external stimuli. To apply this technique with the limited X-ray flux available at a conventional laboratory source, we leverage the contrast enhancement of free-space propagation phase-contrast imaging, achieving an increase in contrast-to-noise ratio of 5.8x. Furthermore, we combine this with iterative reconstruction, using regularisation by a structure-based prior from a high-quality reference scan of the object. This combination of phase-contrast imaging and iterative reconstruction leads to a 29.2x improvement in contrast-to-noise ratio compared to the conventional reconstruction. This enables fully dynamic X-ray microtomography, with a temporal resolution of 9 s at a voxel size of 10.5 $μ$m. We use this to measure the movement of a waterfront in the fine vessels of a wooden skewer, as a representative example of dynamic system evolving on the scale of tens of seconds. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2504_09193 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Dynamic laboratory X-ray phase-contrast microtomography with structure-based prior regularisation Allan, Harry Partridge, Tom Jacob, Joseph Endrizzi, Marco Instrumentation and Detectors Fluid Dynamics Medical Physics X-ray microtomography is a versatile tool allowing the measurement of the 3D structure of optically thick samples. As a non-destructive technique, it is readily adapted to 4D imaging, where a sample can be monitored over time, and especially in conjunction with the application of external stimuli. To apply this technique with the limited X-ray flux available at a conventional laboratory source, we leverage the contrast enhancement of free-space propagation phase-contrast imaging, achieving an increase in contrast-to-noise ratio of 5.8x. Furthermore, we combine this with iterative reconstruction, using regularisation by a structure-based prior from a high-quality reference scan of the object. This combination of phase-contrast imaging and iterative reconstruction leads to a 29.2x improvement in contrast-to-noise ratio compared to the conventional reconstruction. This enables fully dynamic X-ray microtomography, with a temporal resolution of 9 s at a voxel size of 10.5 $μ$m. We use this to measure the movement of a waterfront in the fine vessels of a wooden skewer, as a representative example of dynamic system evolving on the scale of tens of seconds. |
| title | Dynamic laboratory X-ray phase-contrast microtomography with structure-based prior regularisation |
| topic | Instrumentation and Detectors Fluid Dynamics Medical Physics |
| url | https://arxiv.org/abs/2504.09193 |