Analysis of the MICCAI Brain Tumor Segmentation -- Metastases (BraTS-METS) 2025 Lighthouse Challenge: Brain Metastasis Segmentation on Pre- and Post-treatment MRI
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| Format: | Preprint |
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2025
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| author | Maleki, Nazanin Amiruddin, Raisa Moawad, Ahmed W. Yordanov, Nikolay Gkampenis, Athanasios Fehringer, Pascal Umeh, Fabian Chukwurah, Crystal Memon, Fatima Petrovic, Bojan Cramer, Justin Krycia, Mark Shrickel, Elizabeth B. Ikuta, Ichiro Thompson, Gerard Vidal, Lorenna Kosovic, Vilma Goldman-Yassen, Adam E. Hill, Virginia So, Tiffany Mhana, Sedra Alotaibi, Albara Page, Nathan Bhatia, Prisha Guelen, Melisa S. Sharifi, Yasaman Jakovljevic, Marko Abosabie, Salma Abosabie, Sara Ghonim, Mohanad Ghonim, Mohamed Manteghinejad, Amirreza Janas, Anastasia Krantchev, Kiril Adewole, Maruf Albrecht, Jake Anazodo, Udunna Aneja, Sanjay Anwar, Syed Muhammad Bergquist, Timothy Chiang, Veronica Chung, Verena Conte, Gian Marco Dako, Farouk Eddy, James Ezhov, Ivan Khalili, Nastaran Farahani, Keyvan Iglesias, Juan Eugenio Jiang, Zhifan Johanson, Elaine Kazerooni, Anahita Fathi Kofler, Florian LaBella, Dominic Van Leemput, Koen Li, Hongwei Bran Linguraru, Marius George Liu, Xinyang Meier, Zeke Menze, Bjoern H Moy, Harrison Osenberg, Klara Piraud, Marie Reitman, Zachary Shinohara, Russell Takeshi Wang, Chunhao Wiestler, Benedikt Wiggins, Walter Shafique, Umber Willms, Klara Avesta, Arman Bousabarah, Khaled Chakrabarty, Satrajit Gennaro, Nicolo Holler, Wolfgang Kaur, Manpreet LaMontagne, Pamela Lin, MingDe Lost, Jan Marcus, Daniel S. Maresca, Ryan Merkaj, Sarah Pedersen, Gabriel Cassinelli von Reppert, Marc Sotiras, Aristeidis Teytelboym, Oleg Tillmans, Niklas Westerhoff, Malte Youssef, Ayda Godfrey, Devon Floyd, Scott Rauschecker, Andreas Villanueva-Meyer, Javier Pflüger, Irada Cho, Jaeyoung Bendszus, Martin Brugnara, Gianluca Perez-Carillo, Gloria J. Guzman Johnson, Derek R. Kam, Anthony Kwan, Benjamin Yin Ming Lai, Lillian Lall, Neil U. Patro, Satya Narayana Wu, Lei Bansal, Anu Barkhof, Frederik Besada, Cristina Chu, Sammy Druzgal, Jason Dusoi, Alexandru Farage, Luciano Feltrin, Fabricio Fong, Amy Fung, Steve H. Gray, R. Ian Iv, Michael Postma, Alida A. Mahajan, Amit Joyner, David Krumpelman, Chase Letourneau-Guillon, Laurent Lincoln, Christie M. Maros, Mate E. Miller, Elka Morón, Fanny Nimchinsky, Esther A. Ozsarlak, Ozkan Patel, Uresh Rohatgi, Saurabh Saha, Atin Sayah, Anousheh Schwartz, Eric D. Shih, Robert Shiroishi, Mark S. Small, Juan E. Tanwar, Manoj Valerie, Jewels Weinberg, Brent D. White, Matthew L. Young, Robert Zohrabian, Vahe M. Azizova, Aynur Brüßeler, Melanie Maria Theresa Okar, Abdullah Pasquini, Luca Sharifi, Yasaman Singh, Gagandeep Sollmann, Nico Soumala, Theodora Taherzadeh, Mahsa Vollmuth, Philipp Foltyn-Dumitru, Martha Malhotra, Ajay Dellepiane, Francesco Pérez-García, Víctor M. Elhalawani, Hesham de Verdier, Maria Correia Rubaiey, Sanaria Al Armindo, Rui Duarte Ashraf, Kholod Asla, Moamen M. Badawy, Mohamed Bisschop, Jeroen Lomer, Nima Broomand Bukatz, Jan Chen, Jim Cimflova, Petra Corr, Felix Crawley, Alexis Deptula, Lisa Elakhdar, Tasneem Shawali, Islam H. Faghani, Shahriar Frick, Alexandra Gulati, Vaibhav Haider, Muhammad Ammar Hierro, Fátima Dahl, Rasmus Holmboe Jacobs, Sarah Maria Hsieh, Kuang-chun Jim Kandemirli, Sedat G. Kersting, Katharina Kida, Laura Kollia, Sofia Koukoulithras, Ioannis Li, Xiao Abouelatta, Ahmed Mansour, Aya Maria-Zamfirescu, Ruxandra-Catrinel Marsiglia, Marcela Mateo-Camacho, Yohana Sarahi McArthur, Mark McDonnel, Olivia McHugh, Maire Moassefi, Mana Morsi, Samah Mostafa Munteanu, Alexander Nandolia, Khanak K. Naqvi, Syed Raza Nikanpour, Yalda Alnoury, Mostafa Nouh, Abdullah Mohamed Aly Pappafava, Francesca Patel, Markand D. Petrucci, Samantha Rawie, Eric Raymond, Scott Roohani, Borna Sabouhi, Sadeq Garcia, Laura M. Sanchez Shaked, Zoe Suthar, Pokhraj P. Altes, Talissa Isufi, Edvin Dhemesh, Yaseen Gass, Jaime Thacker, Jonathan Tarabishy, Abdul Rahman Turner, Benjamin Vacca, Sebastiano Vilanilam, George K. Warren, Daniel Weiss, David Worede, Fikadu Yousry, Sara Lerebo, Wondwossen Aristizabal, Alejandro Karargyris, Alexandros Kassem, Hasan Pati, Sarthak Sheller, Micah Link, Katherine E. Calabrese, Evan Tahon, Nourel Hoda Nada, Ayman Rudie, Jeffrey D. Reid, Janet Darge, Kassa Abayazeed, Aly H. Lohmann, Philipp Velichko, Yuri S. Bakas, Spyridon Aboian, Mariam |
| author_facet | Maleki, Nazanin Amiruddin, Raisa Moawad, Ahmed W. Yordanov, Nikolay Gkampenis, Athanasios Fehringer, Pascal Umeh, Fabian Chukwurah, Crystal Memon, Fatima Petrovic, Bojan Cramer, Justin Krycia, Mark Shrickel, Elizabeth B. Ikuta, Ichiro Thompson, Gerard Vidal, Lorenna Kosovic, Vilma Goldman-Yassen, Adam E. Hill, Virginia So, Tiffany Mhana, Sedra Alotaibi, Albara Page, Nathan Bhatia, Prisha Guelen, Melisa S. Sharifi, Yasaman Jakovljevic, Marko Abosabie, Salma Abosabie, Sara Ghonim, Mohanad Ghonim, Mohamed Manteghinejad, Amirreza Janas, Anastasia Krantchev, Kiril Adewole, Maruf Albrecht, Jake Anazodo, Udunna Aneja, Sanjay Anwar, Syed Muhammad Bergquist, Timothy Chiang, Veronica Chung, Verena Conte, Gian Marco Dako, Farouk Eddy, James Ezhov, Ivan Khalili, Nastaran Farahani, Keyvan Iglesias, Juan Eugenio Jiang, Zhifan Johanson, Elaine Kazerooni, Anahita Fathi Kofler, Florian LaBella, Dominic Van Leemput, Koen Li, Hongwei Bran Linguraru, Marius George Liu, Xinyang Meier, Zeke Menze, Bjoern H Moy, Harrison Osenberg, Klara Piraud, Marie Reitman, Zachary Shinohara, Russell Takeshi Wang, Chunhao Wiestler, Benedikt Wiggins, Walter Shafique, Umber Willms, Klara Avesta, Arman Bousabarah, Khaled Chakrabarty, Satrajit Gennaro, Nicolo Holler, Wolfgang Kaur, Manpreet LaMontagne, Pamela Lin, MingDe Lost, Jan Marcus, Daniel S. Maresca, Ryan Merkaj, Sarah Pedersen, Gabriel Cassinelli von Reppert, Marc Sotiras, Aristeidis Teytelboym, Oleg Tillmans, Niklas Westerhoff, Malte Youssef, Ayda Godfrey, Devon Floyd, Scott Rauschecker, Andreas Villanueva-Meyer, Javier Pflüger, Irada Cho, Jaeyoung Bendszus, Martin Brugnara, Gianluca Perez-Carillo, Gloria J. Guzman Johnson, Derek R. Kam, Anthony Kwan, Benjamin Yin Ming Lai, Lillian Lall, Neil U. Patro, Satya Narayana Wu, Lei Bansal, Anu Barkhof, Frederik Besada, Cristina Chu, Sammy Druzgal, Jason Dusoi, Alexandru Farage, Luciano Feltrin, Fabricio Fong, Amy Fung, Steve H. Gray, R. Ian Iv, Michael Postma, Alida A. Mahajan, Amit Joyner, David Krumpelman, Chase Letourneau-Guillon, Laurent Lincoln, Christie M. Maros, Mate E. Miller, Elka Morón, Fanny Nimchinsky, Esther A. Ozsarlak, Ozkan Patel, Uresh Rohatgi, Saurabh Saha, Atin Sayah, Anousheh Schwartz, Eric D. Shih, Robert Shiroishi, Mark S. Small, Juan E. Tanwar, Manoj Valerie, Jewels Weinberg, Brent D. White, Matthew L. Young, Robert Zohrabian, Vahe M. Azizova, Aynur Brüßeler, Melanie Maria Theresa Okar, Abdullah Pasquini, Luca Sharifi, Yasaman Singh, Gagandeep Sollmann, Nico Soumala, Theodora Taherzadeh, Mahsa Vollmuth, Philipp Foltyn-Dumitru, Martha Malhotra, Ajay Dellepiane, Francesco Pérez-García, Víctor M. Elhalawani, Hesham de Verdier, Maria Correia Rubaiey, Sanaria Al Armindo, Rui Duarte Ashraf, Kholod Asla, Moamen M. Badawy, Mohamed Bisschop, Jeroen Lomer, Nima Broomand Bukatz, Jan Chen, Jim Cimflova, Petra Corr, Felix Crawley, Alexis Deptula, Lisa Elakhdar, Tasneem Shawali, Islam H. Faghani, Shahriar Frick, Alexandra Gulati, Vaibhav Haider, Muhammad Ammar Hierro, Fátima Dahl, Rasmus Holmboe Jacobs, Sarah Maria Hsieh, Kuang-chun Jim Kandemirli, Sedat G. Kersting, Katharina Kida, Laura Kollia, Sofia Koukoulithras, Ioannis Li, Xiao Abouelatta, Ahmed Mansour, Aya Maria-Zamfirescu, Ruxandra-Catrinel Marsiglia, Marcela Mateo-Camacho, Yohana Sarahi McArthur, Mark McDonnel, Olivia McHugh, Maire Moassefi, Mana Morsi, Samah Mostafa Munteanu, Alexander Nandolia, Khanak K. Naqvi, Syed Raza Nikanpour, Yalda Alnoury, Mostafa Nouh, Abdullah Mohamed Aly Pappafava, Francesca Patel, Markand D. Petrucci, Samantha Rawie, Eric Raymond, Scott Roohani, Borna Sabouhi, Sadeq Garcia, Laura M. Sanchez Shaked, Zoe Suthar, Pokhraj P. Altes, Talissa Isufi, Edvin Dhemesh, Yaseen Gass, Jaime Thacker, Jonathan Tarabishy, Abdul Rahman Turner, Benjamin Vacca, Sebastiano Vilanilam, George K. Warren, Daniel Weiss, David Worede, Fikadu Yousry, Sara Lerebo, Wondwossen Aristizabal, Alejandro Karargyris, Alexandros Kassem, Hasan Pati, Sarthak Sheller, Micah Link, Katherine E. Calabrese, Evan Tahon, Nourel Hoda Nada, Ayman Rudie, Jeffrey D. Reid, Janet Darge, Kassa Abayazeed, Aly H. Lohmann, Philipp Velichko, Yuri S. Bakas, Spyridon Aboian, Mariam |
| contents | Despite continuous advancements in cancer treatment, brain metastatic disease remains a significant complication of primary cancer and is associated with an unfavorable prognosis. One approach for improving diagnosis, management, and outcomes is to implement algorithms based on artificial intelligence for the automated segmentation of both pre- and post-treatment MRI brain images. Such algorithms rely on volumetric criteria for lesion identification and treatment response assessment, which are still not available in clinical practice. Therefore, it is critical to establish tools for rapid volumetric segmentations methods that can be translated to clinical practice and that are trained on high quality annotated data. The BraTS-METS 2025 Lighthouse Challenge aims to address this critical need by establishing inter-rater and intra-rater variability in dataset annotation by generating high quality annotated datasets from four individual instances of segmentation by neuroradiologists while being recorded on video (two instances doing "from scratch" and two instances after AI pre-segmentation). This high-quality annotated dataset will be used for testing phase in 2025 Lighthouse challenge and will be publicly released at the completion of the challenge. The 2025 Lighthouse challenge will also release the 2023 and 2024 segmented datasets that were annotated using an established pipeline of pre-segmentation, student annotation, two neuroradiologists checking, and one neuroradiologist finalizing the process. It builds upon its previous edition by including post-treatment cases in the dataset. Using these high-quality annotated datasets, the 2025 Lighthouse challenge plans to test benchmark algorithms for automated segmentation of pre-and post-treatment brain metastases (BM), trained on diverse and multi-institutional datasets of MRI images obtained from patients with brain metastases. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_12527 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Analysis of the MICCAI Brain Tumor Segmentation -- Metastases (BraTS-METS) 2025 Lighthouse Challenge: Brain Metastasis Segmentation on Pre- and Post-treatment MRI Maleki, Nazanin Amiruddin, Raisa Moawad, Ahmed W. Yordanov, Nikolay Gkampenis, Athanasios Fehringer, Pascal Umeh, Fabian Chukwurah, Crystal Memon, Fatima Petrovic, Bojan Cramer, Justin Krycia, Mark Shrickel, Elizabeth B. Ikuta, Ichiro Thompson, Gerard Vidal, Lorenna Kosovic, Vilma Goldman-Yassen, Adam E. Hill, Virginia So, Tiffany Mhana, Sedra Alotaibi, Albara Page, Nathan Bhatia, Prisha Guelen, Melisa S. Sharifi, Yasaman Jakovljevic, Marko Abosabie, Salma Abosabie, Sara Ghonim, Mohanad Ghonim, Mohamed Manteghinejad, Amirreza Janas, Anastasia Krantchev, Kiril Adewole, Maruf Albrecht, Jake Anazodo, Udunna Aneja, Sanjay Anwar, Syed Muhammad Bergquist, Timothy Chiang, Veronica Chung, Verena Conte, Gian Marco Dako, Farouk Eddy, James Ezhov, Ivan Khalili, Nastaran Farahani, Keyvan Iglesias, Juan Eugenio Jiang, Zhifan Johanson, Elaine Kazerooni, Anahita Fathi Kofler, Florian LaBella, Dominic Van Leemput, Koen Li, Hongwei Bran Linguraru, Marius George Liu, Xinyang Meier, Zeke Menze, Bjoern H Moy, Harrison Osenberg, Klara Piraud, Marie Reitman, Zachary Shinohara, Russell Takeshi Wang, Chunhao Wiestler, Benedikt Wiggins, Walter Shafique, Umber Willms, Klara Avesta, Arman Bousabarah, Khaled Chakrabarty, Satrajit Gennaro, Nicolo Holler, Wolfgang Kaur, Manpreet LaMontagne, Pamela Lin, MingDe Lost, Jan Marcus, Daniel S. Maresca, Ryan Merkaj, Sarah Pedersen, Gabriel Cassinelli von Reppert, Marc Sotiras, Aristeidis Teytelboym, Oleg Tillmans, Niklas Westerhoff, Malte Youssef, Ayda Godfrey, Devon Floyd, Scott Rauschecker, Andreas Villanueva-Meyer, Javier Pflüger, Irada Cho, Jaeyoung Bendszus, Martin Brugnara, Gianluca Perez-Carillo, Gloria J. Guzman Johnson, Derek R. Kam, Anthony Kwan, Benjamin Yin Ming Lai, Lillian Lall, Neil U. Patro, Satya Narayana Wu, Lei Bansal, Anu Barkhof, Frederik Besada, Cristina Chu, Sammy Druzgal, Jason Dusoi, Alexandru Farage, Luciano Feltrin, Fabricio Fong, Amy Fung, Steve H. Gray, R. Ian Iv, Michael Postma, Alida A. Mahajan, Amit Joyner, David Krumpelman, Chase Letourneau-Guillon, Laurent Lincoln, Christie M. Maros, Mate E. Miller, Elka Morón, Fanny Nimchinsky, Esther A. Ozsarlak, Ozkan Patel, Uresh Rohatgi, Saurabh Saha, Atin Sayah, Anousheh Schwartz, Eric D. Shih, Robert Shiroishi, Mark S. Small, Juan E. Tanwar, Manoj Valerie, Jewels Weinberg, Brent D. White, Matthew L. Young, Robert Zohrabian, Vahe M. Azizova, Aynur Brüßeler, Melanie Maria Theresa Okar, Abdullah Pasquini, Luca Sharifi, Yasaman Singh, Gagandeep Sollmann, Nico Soumala, Theodora Taherzadeh, Mahsa Vollmuth, Philipp Foltyn-Dumitru, Martha Malhotra, Ajay Dellepiane, Francesco Pérez-García, Víctor M. Elhalawani, Hesham de Verdier, Maria Correia Rubaiey, Sanaria Al Armindo, Rui Duarte Ashraf, Kholod Asla, Moamen M. Badawy, Mohamed Bisschop, Jeroen Lomer, Nima Broomand Bukatz, Jan Chen, Jim Cimflova, Petra Corr, Felix Crawley, Alexis Deptula, Lisa Elakhdar, Tasneem Shawali, Islam H. Faghani, Shahriar Frick, Alexandra Gulati, Vaibhav Haider, Muhammad Ammar Hierro, Fátima Dahl, Rasmus Holmboe Jacobs, Sarah Maria Hsieh, Kuang-chun Jim Kandemirli, Sedat G. Kersting, Katharina Kida, Laura Kollia, Sofia Koukoulithras, Ioannis Li, Xiao Abouelatta, Ahmed Mansour, Aya Maria-Zamfirescu, Ruxandra-Catrinel Marsiglia, Marcela Mateo-Camacho, Yohana Sarahi McArthur, Mark McDonnel, Olivia McHugh, Maire Moassefi, Mana Morsi, Samah Mostafa Munteanu, Alexander Nandolia, Khanak K. Naqvi, Syed Raza Nikanpour, Yalda Alnoury, Mostafa Nouh, Abdullah Mohamed Aly Pappafava, Francesca Patel, Markand D. Petrucci, Samantha Rawie, Eric Raymond, Scott Roohani, Borna Sabouhi, Sadeq Garcia, Laura M. Sanchez Shaked, Zoe Suthar, Pokhraj P. Altes, Talissa Isufi, Edvin Dhemesh, Yaseen Gass, Jaime Thacker, Jonathan Tarabishy, Abdul Rahman Turner, Benjamin Vacca, Sebastiano Vilanilam, George K. Warren, Daniel Weiss, David Worede, Fikadu Yousry, Sara Lerebo, Wondwossen Aristizabal, Alejandro Karargyris, Alexandros Kassem, Hasan Pati, Sarthak Sheller, Micah Link, Katherine E. Calabrese, Evan Tahon, Nourel Hoda Nada, Ayman Rudie, Jeffrey D. Reid, Janet Darge, Kassa Abayazeed, Aly H. Lohmann, Philipp Velichko, Yuri S. Bakas, Spyridon Aboian, Mariam Other Quantitative Biology Image and Video Processing Despite continuous advancements in cancer treatment, brain metastatic disease remains a significant complication of primary cancer and is associated with an unfavorable prognosis. One approach for improving diagnosis, management, and outcomes is to implement algorithms based on artificial intelligence for the automated segmentation of both pre- and post-treatment MRI brain images. Such algorithms rely on volumetric criteria for lesion identification and treatment response assessment, which are still not available in clinical practice. Therefore, it is critical to establish tools for rapid volumetric segmentations methods that can be translated to clinical practice and that are trained on high quality annotated data. The BraTS-METS 2025 Lighthouse Challenge aims to address this critical need by establishing inter-rater and intra-rater variability in dataset annotation by generating high quality annotated datasets from four individual instances of segmentation by neuroradiologists while being recorded on video (two instances doing "from scratch" and two instances after AI pre-segmentation). This high-quality annotated dataset will be used for testing phase in 2025 Lighthouse challenge and will be publicly released at the completion of the challenge. The 2025 Lighthouse challenge will also release the 2023 and 2024 segmented datasets that were annotated using an established pipeline of pre-segmentation, student annotation, two neuroradiologists checking, and one neuroradiologist finalizing the process. It builds upon its previous edition by including post-treatment cases in the dataset. Using these high-quality annotated datasets, the 2025 Lighthouse challenge plans to test benchmark algorithms for automated segmentation of pre-and post-treatment brain metastases (BM), trained on diverse and multi-institutional datasets of MRI images obtained from patients with brain metastases. |
| title | Analysis of the MICCAI Brain Tumor Segmentation -- Metastases (BraTS-METS) 2025 Lighthouse Challenge: Brain Metastasis Segmentation on Pre- and Post-treatment MRI |
| topic | Other Quantitative Biology Image and Video Processing |
| url | https://arxiv.org/abs/2504.12527 |