Quantitative Analysis of Cell Membrane Tension in Time-Series Imaging and A Minimal Lattice Model of Single Cell Motion
Fuente:
arXiv
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Preprint |
| Published: |
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866910915408953344 |
|---|---|
| author | Nishitani, Hiroki Miura, Takashi |
| author_facet | Nishitani, Hiroki Miura, Takashi |
| contents | Cell membrane tension directly influences various cellular functions. In this study, we developed a method to estimate surface tension from time-series data. We obtained the curvature-velocity relationship from time-series of binarized cell shape images, and the effective surface tension term was calculated from linear regression.
During the process, we observed an S-shaped pattern in the curvature-velocity relationship. To understand the dynamics, we constructed a minimal lattice model describing single-cell motion. The model consists of surface tension and protrusion formation, and the characteristic parameters are obtained from experimental observations. We found that similar patterns emerged in the curvature-velocity relationship. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_14887 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Quantitative Analysis of Cell Membrane Tension in Time-Series Imaging and A Minimal Lattice Model of Single Cell Motion Nishitani, Hiroki Miura, Takashi Cell Behavior Cell membrane tension directly influences various cellular functions. In this study, we developed a method to estimate surface tension from time-series data. We obtained the curvature-velocity relationship from time-series of binarized cell shape images, and the effective surface tension term was calculated from linear regression. During the process, we observed an S-shaped pattern in the curvature-velocity relationship. To understand the dynamics, we constructed a minimal lattice model describing single-cell motion. The model consists of surface tension and protrusion formation, and the characteristic parameters are obtained from experimental observations. We found that similar patterns emerged in the curvature-velocity relationship. |
| title | Quantitative Analysis of Cell Membrane Tension in Time-Series Imaging and A Minimal Lattice Model of Single Cell Motion |
| topic | Cell Behavior |
| url | https://arxiv.org/abs/2504.14887 |