Learning via mechanosensitivity and activity in cytoskeletal networks
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arXiv
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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866917992925757440 |
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| author | Banerjee, Deb S. Falk, Martin J. Gardel, Margaret L Walczak, Aleksandra M. Mora, Thierry Vaikuntanathan, Suriyanarayanan |
| author_facet | Banerjee, Deb S. Falk, Martin J. Gardel, Margaret L Walczak, Aleksandra M. Mora, Thierry Vaikuntanathan, Suriyanarayanan |
| contents | In this work we show how a network inspired by a coarse-grained description of actomyosin cytoskeleton can learn - in a contrastive learning framework - from environmental perturbations if it is endowed with mechanosensitive proteins and motors. Our work is a proof of principle for how force-sensitive proteins and molecular motors can form the basis of a general strategy to learn in biological systems. Our work identifies a minimal biologically plausible learning mechanism and also explores its implications for commonly occuring phenomenolgy such as adaptation and homeostatis. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2504_15107 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Learning via mechanosensitivity and activity in cytoskeletal networks Banerjee, Deb S. Falk, Martin J. Gardel, Margaret L Walczak, Aleksandra M. Mora, Thierry Vaikuntanathan, Suriyanarayanan Soft Condensed Matter Biological Physics In this work we show how a network inspired by a coarse-grained description of actomyosin cytoskeleton can learn - in a contrastive learning framework - from environmental perturbations if it is endowed with mechanosensitive proteins and motors. Our work is a proof of principle for how force-sensitive proteins and molecular motors can form the basis of a general strategy to learn in biological systems. Our work identifies a minimal biologically plausible learning mechanism and also explores its implications for commonly occuring phenomenolgy such as adaptation and homeostatis. |
| title | Learning via mechanosensitivity and activity in cytoskeletal networks |
| topic | Soft Condensed Matter Biological Physics |
| url | https://arxiv.org/abs/2504.15107 |