The e-Partitioning Principle of False Discovery Rate Control

Fuente: arXiv
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Autori principali: Goeman, Jelle, de Heide, Rianne, Solari, Aldo
Natura: Preprint
Pubblicazione: 2025
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author Goeman, Jelle
de Heide, Rianne
Solari, Aldo
author_facet Goeman, Jelle
de Heide, Rianne
Solari, Aldo
contents We present a novel necessary and sufficient principle for False Discovery Rate (FDR) control. This e-Partitioning Principle says that a procedure controls FDR if and only if it is a special case of a general e-Partitioning procedure. By writing existing methods as special cases of this procedure, we can achieve uniform improvements of these methods, and we show this in particular for the eBH, BY and Su methods. We also show that methods developed using the $e$-Partitioning Principle have several valuable properties. They generally control FDR not just for one rejected set, but simultaneously over many, allowing post hoc flexibility for the researcher in the final choice of the rejected hypotheses. Under some conditions, they also allow for post hoc adjustment of the error rate, choosing the FDR level $α$ post hoc, or switching to familywise error control after seeing the data. In addition, e-Partitioning allows FDR control methods to exploit logical relationships between hypotheses to gain power.
format Preprint
id arxiv_https___arxiv_org_abs_2504_15946
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle The e-Partitioning Principle of False Discovery Rate Control
Goeman, Jelle
de Heide, Rianne
Solari, Aldo
Statistics Theory
We present a novel necessary and sufficient principle for False Discovery Rate (FDR) control. This e-Partitioning Principle says that a procedure controls FDR if and only if it is a special case of a general e-Partitioning procedure. By writing existing methods as special cases of this procedure, we can achieve uniform improvements of these methods, and we show this in particular for the eBH, BY and Su methods. We also show that methods developed using the $e$-Partitioning Principle have several valuable properties. They generally control FDR not just for one rejected set, but simultaneously over many, allowing post hoc flexibility for the researcher in the final choice of the rejected hypotheses. Under some conditions, they also allow for post hoc adjustment of the error rate, choosing the FDR level $α$ post hoc, or switching to familywise error control after seeing the data. In addition, e-Partitioning allows FDR control methods to exploit logical relationships between hypotheses to gain power.
title The e-Partitioning Principle of False Discovery Rate Control
topic Statistics Theory
url https://arxiv.org/abs/2504.15946