Rootlets-based registration to the spinal cord PAM50 template
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arXiv
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| Autores principales: | , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| Acceso en línea: | |
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| _version_ | 1866909598006378496 |
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| author | Bédard, Sandrine Valošek, Jan Oliva, Valeria Weber II, Kenneth A. Cohen-Adad, Julien |
| author_facet | Bédard, Sandrine Valošek, Jan Oliva, Valeria Weber II, Kenneth A. Cohen-Adad, Julien |
| contents | Spinal cord functional MRI studies require precise localization of spinal levels for reliable voxelwise group analyses. Traditional template-based registration of the spinal cord uses intervertebral discs for alignment. However, substantial anatomical variability across individuals exists between vertebral and spinal levels. This study proposes a novel registration approach that leverages spinal nerve rootlets to improve alignment accuracy and reproducibility across individuals. We developed a registration method leveraging dorsal cervical rootlets segmentation and aligning them non-linearly with the PAM50 spinal cord template. Validation was performed on a multi-subject, multi-site dataset (n=267, 44 sites) and a multi-subject dataset with various neck positions (n=10, 3 sessions). We further validated the method on task-based functional MRI (n=23) to compare group-level activation maps using rootlet-based registration to traditional disc-based methods. Rootlet-based registration showed superior alignment across individuals compared to the traditional disc-based method. Notably, rootlet positions were more stable across neck positions. Group-level analysis of task-based functional MRI using rootlet-based increased Z scores and activation cluster size compared to disc-based registration (number of active voxels from 3292 to 7978). Rootlet-based registration enhances both inter- and intra-subject anatomical alignment and yields better spatial normalization for group-level fMRI analyses. Our findings highlight the potential of rootlet-based registration to improve the precision and reliability of spinal cord neuroimaging group analysis. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2505_00115 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Rootlets-based registration to the spinal cord PAM50 template Bédard, Sandrine Valošek, Jan Oliva, Valeria Weber II, Kenneth A. Cohen-Adad, Julien Image and Video Processing Computer Vision and Pattern Recognition Spinal cord functional MRI studies require precise localization of spinal levels for reliable voxelwise group analyses. Traditional template-based registration of the spinal cord uses intervertebral discs for alignment. However, substantial anatomical variability across individuals exists between vertebral and spinal levels. This study proposes a novel registration approach that leverages spinal nerve rootlets to improve alignment accuracy and reproducibility across individuals. We developed a registration method leveraging dorsal cervical rootlets segmentation and aligning them non-linearly with the PAM50 spinal cord template. Validation was performed on a multi-subject, multi-site dataset (n=267, 44 sites) and a multi-subject dataset with various neck positions (n=10, 3 sessions). We further validated the method on task-based functional MRI (n=23) to compare group-level activation maps using rootlet-based registration to traditional disc-based methods. Rootlet-based registration showed superior alignment across individuals compared to the traditional disc-based method. Notably, rootlet positions were more stable across neck positions. Group-level analysis of task-based functional MRI using rootlet-based increased Z scores and activation cluster size compared to disc-based registration (number of active voxels from 3292 to 7978). Rootlet-based registration enhances both inter- and intra-subject anatomical alignment and yields better spatial normalization for group-level fMRI analyses. Our findings highlight the potential of rootlet-based registration to improve the precision and reliability of spinal cord neuroimaging group analysis. |
| title | Rootlets-based registration to the spinal cord PAM50 template |
| topic | Image and Video Processing Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2505.00115 |