TumorTwin: A python framework for patient-specific digital twins in oncology
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arXiv
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| Autores principales: | , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| _version_ | 1866918006078046208 |
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| author | Kapteyn, Michael Chaudhuri, Anirban Lima, Ernesto A. B. F. Pash, Graham Bravo, Rafael Willcox, Karen Yankeelov, Thomas E. Hormuth II, David A. |
| author_facet | Kapteyn, Michael Chaudhuri, Anirban Lima, Ernesto A. B. F. Pash, Graham Bravo, Rafael Willcox, Karen Yankeelov, Thomas E. Hormuth II, David A. |
| contents | Background: Advances in the theory and methods of computational oncology have enabled accurate characterization and prediction of tumor growth and treatment response on a patient-specific basis. This capability can be integrated into a digital twin framework in which bi-directional data-flow between the physical tumor and the digital tumor facilitate dynamic model re-calibration, uncertainty quantification, and clinical decision-support via recommendation of optimal therapeutic interventions. However, many digital twin frameworks rely on bespoke implementations tailored to each disease site, modeling choice, and algorithmic implementation.
Findings: We present TumorTwin, a modular software framework for initializing, updating, and leveraging patient-specific cancer tumor digital twins. TumorTwin is publicly available as a Python package, with associated documentation, datasets, and tutorials. Novel contributions include the development of a patient-data structure adaptable to different disease sites, a modular architecture to enable the composition of different data, model, solver, and optimization objects, and CPU- or GPU-parallelized implementations of forward model solves and gradient computations. We demonstrate the functionality of TumorTwin via an in silico dataset of high-grade glioma growth and response to radiation therapy.
Conclusions: The TumorTwin framework enables rapid prototyping and testing of image-guided oncology digital twins. This allows researchers to systematically investigate different models, algorithms, disease sites, or treatment decisions while leveraging robust numerical and computational infrastructure. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2505_00670 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | TumorTwin: A python framework for patient-specific digital twins in oncology Kapteyn, Michael Chaudhuri, Anirban Lima, Ernesto A. B. F. Pash, Graham Bravo, Rafael Willcox, Karen Yankeelov, Thomas E. Hormuth II, David A. Medical Physics Mathematical Software Background: Advances in the theory and methods of computational oncology have enabled accurate characterization and prediction of tumor growth and treatment response on a patient-specific basis. This capability can be integrated into a digital twin framework in which bi-directional data-flow between the physical tumor and the digital tumor facilitate dynamic model re-calibration, uncertainty quantification, and clinical decision-support via recommendation of optimal therapeutic interventions. However, many digital twin frameworks rely on bespoke implementations tailored to each disease site, modeling choice, and algorithmic implementation. Findings: We present TumorTwin, a modular software framework for initializing, updating, and leveraging patient-specific cancer tumor digital twins. TumorTwin is publicly available as a Python package, with associated documentation, datasets, and tutorials. Novel contributions include the development of a patient-data structure adaptable to different disease sites, a modular architecture to enable the composition of different data, model, solver, and optimization objects, and CPU- or GPU-parallelized implementations of forward model solves and gradient computations. We demonstrate the functionality of TumorTwin via an in silico dataset of high-grade glioma growth and response to radiation therapy. Conclusions: The TumorTwin framework enables rapid prototyping and testing of image-guided oncology digital twins. This allows researchers to systematically investigate different models, algorithms, disease sites, or treatment decisions while leveraging robust numerical and computational infrastructure. |
| title | TumorTwin: A python framework for patient-specific digital twins in oncology |
| topic | Medical Physics Mathematical Software |
| url | https://arxiv.org/abs/2505.00670 |