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Main Authors: Caragliano, Alice Natalina, Tacconi, Claudia, Greco, Carlo, Nibid, Lorenzo, Ippolito, Edy, Fiore, Michele, Perrone, Giuseppe, Ramella, Sara, Soda, Paolo, Guarrasi, Valerio
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2505.01390
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author Caragliano, Alice Natalina
Tacconi, Claudia
Greco, Carlo
Nibid, Lorenzo
Ippolito, Edy
Fiore, Michele
Perrone, Giuseppe
Ramella, Sara
Soda, Paolo
Guarrasi, Valerio
author_facet Caragliano, Alice Natalina
Tacconi, Claudia
Greco, Carlo
Nibid, Lorenzo
Ippolito, Edy
Fiore, Michele
Perrone, Giuseppe
Ramella, Sara
Soda, Paolo
Guarrasi, Valerio
contents This study proposes a novel approach combining Multimodal Deep Learning with intrinsic eXplainable Artificial Intelligence techniques to predict pathological response in non-small cell lung cancer patients undergoing neoadjuvant therapy. Due to the limitations of existing radiomics and unimodal deep learning approaches, we introduce an intermediate fusion strategy that integrates imaging and clinical data, enabling efficient interaction between data modalities. The proposed Multimodal Doctor-in-the-Loop method further enhances clinical relevance by embedding clinicians' domain knowledge directly into the training process, guiding the model's focus gradually from broader lung regions to specific lesions. Results demonstrate improved predictive accuracy and explainability, providing insights into optimal data integration strategies for clinical applications.
format Preprint
id arxiv_https___arxiv_org_abs_2505_01390
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Multimodal Doctor-in-the-Loop: A Clinically-Guided Explainable Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer
Caragliano, Alice Natalina
Tacconi, Claudia
Greco, Carlo
Nibid, Lorenzo
Ippolito, Edy
Fiore, Michele
Perrone, Giuseppe
Ramella, Sara
Soda, Paolo
Guarrasi, Valerio
Computer Vision and Pattern Recognition
Artificial Intelligence
Machine Learning
This study proposes a novel approach combining Multimodal Deep Learning with intrinsic eXplainable Artificial Intelligence techniques to predict pathological response in non-small cell lung cancer patients undergoing neoadjuvant therapy. Due to the limitations of existing radiomics and unimodal deep learning approaches, we introduce an intermediate fusion strategy that integrates imaging and clinical data, enabling efficient interaction between data modalities. The proposed Multimodal Doctor-in-the-Loop method further enhances clinical relevance by embedding clinicians' domain knowledge directly into the training process, guiding the model's focus gradually from broader lung regions to specific lesions. Results demonstrate improved predictive accuracy and explainability, providing insights into optimal data integration strategies for clinical applications.
title Multimodal Doctor-in-the-Loop: A Clinically-Guided Explainable Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer
topic Computer Vision and Pattern Recognition
Artificial Intelligence
Machine Learning
url https://arxiv.org/abs/2505.01390