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| Format: | Preprint |
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2025
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| Online Access: | https://arxiv.org/abs/2505.07687 |
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| _version_ | 1866917297698897920 |
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| author | Yuan, Feng |
| author_facet | Yuan, Feng |
| contents | Multi-modal medical image synthesis is pivotal for alleviating clinical data scarcity, yet existing methods fail to reconcile global anatomical consistency with high-fidelity local detail. We propose FermatSyn, which addresses three persistent limitations: (1)~a SAM2-based Prior Encoder that injects domain-aware anatomical knowledge via Lo-RA$^{+}$ efficient fine-tuning of a frozen SAM2 Vision Transformer; (2)~a Hierarchical Residual Downsampling Module (HRDM) coupled with a Cross-scale Integration Network (CIN) that preserves high-frequency lesion details and adaptively fuses global--local representations; and (3)~a continuity constrained Fermat Spiral Scanning strategy within a Bidirectional Fermat Scan Mamba (BFS-Mamba), constructing an approximately isotropic receptive field that substantially reduces the directional bias of raster or spiral serialization. Experiments on SynthRAD2023, BraTS2019, BraTS-MEN, and BraTS-MET show FermatSyn surpasses state-of-the-art methods in PSNR, SSIM, FID, and 3D structural consistency. Downstream segmentation on synthesized images yields no significant difference from real-image training ($p{>}0.05$), confirming clinical utility. Code will be released upon publication. \keywords{Medical image synthesis \and SAM2 \and Mamba \and Fermat spiral scanning \and Anatomical prior \and Cross-modal} |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2505_07687 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | FermatSyn: SAM2-Enhanced Bidirectional Mamba with Isotropic Spiral Scanning for Multi-Modal Medical Image Synthesis Yuan, Feng Image and Video Processing Computer Vision and Pattern Recognition Multi-modal medical image synthesis is pivotal for alleviating clinical data scarcity, yet existing methods fail to reconcile global anatomical consistency with high-fidelity local detail. We propose FermatSyn, which addresses three persistent limitations: (1)~a SAM2-based Prior Encoder that injects domain-aware anatomical knowledge via Lo-RA$^{+}$ efficient fine-tuning of a frozen SAM2 Vision Transformer; (2)~a Hierarchical Residual Downsampling Module (HRDM) coupled with a Cross-scale Integration Network (CIN) that preserves high-frequency lesion details and adaptively fuses global--local representations; and (3)~a continuity constrained Fermat Spiral Scanning strategy within a Bidirectional Fermat Scan Mamba (BFS-Mamba), constructing an approximately isotropic receptive field that substantially reduces the directional bias of raster or spiral serialization. Experiments on SynthRAD2023, BraTS2019, BraTS-MEN, and BraTS-MET show FermatSyn surpasses state-of-the-art methods in PSNR, SSIM, FID, and 3D structural consistency. Downstream segmentation on synthesized images yields no significant difference from real-image training ($p{>}0.05$), confirming clinical utility. Code will be released upon publication. \keywords{Medical image synthesis \and SAM2 \and Mamba \and Fermat spiral scanning \and Anatomical prior \and Cross-modal} |
| title | FermatSyn: SAM2-Enhanced Bidirectional Mamba with Isotropic Spiral Scanning for Multi-Modal Medical Image Synthesis |
| topic | Image and Video Processing Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2505.07687 |