EpiLLM: Unlocking the Potential of Large Language Models in Epidemic Forecasting

Fuente: arXiv
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Main Authors: Gong, Chenghua, Sun, Rui, Zheng, Yuhao, Zhang, Juyuan, Gu, Tianjun, Pan, Liming, Lv, Linyuan
Format: Preprint
Published: 2025
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author Gong, Chenghua
Sun, Rui
Zheng, Yuhao
Zhang, Juyuan
Gu, Tianjun
Pan, Liming
Lv, Linyuan
author_facet Gong, Chenghua
Sun, Rui
Zheng, Yuhao
Zhang, Juyuan
Gu, Tianjun
Pan, Liming
Lv, Linyuan
contents Advanced epidemic forecasting is critical for enabling precision containment strategies, highlighting its strategic importance for public health security. While recent advances in Large Language Models (LLMs) have demonstrated effectiveness as foundation models for domain-specific tasks, their potential for epidemic forecasting remains largely unexplored. In this paper, we introduce EpiLLM, a novel LLM-based framework tailored for spatio-temporal epidemic forecasting. Considering the key factors in real-world epidemic transmission: infection cases and human mobility, we introduce a dual-branch architecture to achieve fine-grained token-level alignment between such complex epidemic patterns and language tokens for LLM adaptation. To unleash the multi-step forecasting and generalization potential of LLM architectures, we propose an autoregressive modeling paradigm that reformulates the epidemic forecasting task into next-token prediction. To further enhance LLM perception of epidemics, we introduce spatio-temporal prompt learning techniques, which strengthen forecasting capabilities from a data-driven perspective. Extensive experiments show that EpiLLM significantly outperforms existing baselines on real-world COVID-19 datasets and exhibits scaling behavior characteristic of LLMs.
format Preprint
id arxiv_https___arxiv_org_abs_2505_12738
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle EpiLLM: Unlocking the Potential of Large Language Models in Epidemic Forecasting
Gong, Chenghua
Sun, Rui
Zheng, Yuhao
Zhang, Juyuan
Gu, Tianjun
Pan, Liming
Lv, Linyuan
Machine Learning
Artificial Intelligence
Social and Information Networks
Advanced epidemic forecasting is critical for enabling precision containment strategies, highlighting its strategic importance for public health security. While recent advances in Large Language Models (LLMs) have demonstrated effectiveness as foundation models for domain-specific tasks, their potential for epidemic forecasting remains largely unexplored. In this paper, we introduce EpiLLM, a novel LLM-based framework tailored for spatio-temporal epidemic forecasting. Considering the key factors in real-world epidemic transmission: infection cases and human mobility, we introduce a dual-branch architecture to achieve fine-grained token-level alignment between such complex epidemic patterns and language tokens for LLM adaptation. To unleash the multi-step forecasting and generalization potential of LLM architectures, we propose an autoregressive modeling paradigm that reformulates the epidemic forecasting task into next-token prediction. To further enhance LLM perception of epidemics, we introduce spatio-temporal prompt learning techniques, which strengthen forecasting capabilities from a data-driven perspective. Extensive experiments show that EpiLLM significantly outperforms existing baselines on real-world COVID-19 datasets and exhibits scaling behavior characteristic of LLMs.
title EpiLLM: Unlocking the Potential of Large Language Models in Epidemic Forecasting
topic Machine Learning
Artificial Intelligence
Social and Information Networks
url https://arxiv.org/abs/2505.12738