VesselGPT: Autoregressive Modeling of Vascular Geometry

Fuente: arXiv
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Main Authors: Feldman, Paula, Sinnona, Martin, Delrieux, Claudio, Siless, Viviana, Iarussi, Emmanuel
Format: Preprint
Published: 2025
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author Feldman, Paula
Sinnona, Martin
Delrieux, Claudio
Siless, Viviana
Iarussi, Emmanuel
author_facet Feldman, Paula
Sinnona, Martin
Delrieux, Claudio
Siless, Viviana
Iarussi, Emmanuel
contents Anatomical trees are critical for clinical diagnosis and treatment planning, yet their complex and diverse geometry make accurate representation a significant challenge. Motivated by the latest advances in large language models, we introduce an autoregressive method for synthesizing anatomical trees. Our approach first embeds vessel structures into a learned discrete vocabulary using a VQ-VAE architecture, then models their generation autoregressively with a GPT-2 model. This method effectively captures intricate geometries and branching patterns, enabling realistic vascular tree synthesis. Comprehensive qualitative and quantitative evaluations reveal that our technique achieves high-fidelity tree reconstruction with compact discrete representations. Moreover, our B-spline representation of vessel cross-sections preserves critical morphological details that are often overlooked in previous' methods parameterizations. To the best of our knowledge, this work is the first to generate blood vessels in an autoregressive manner. Code is available at https://github.com/LIA-DiTella/VesselGPT-MICCAI.
format Preprint
id arxiv_https___arxiv_org_abs_2505_13318
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle VesselGPT: Autoregressive Modeling of Vascular Geometry
Feldman, Paula
Sinnona, Martin
Delrieux, Claudio
Siless, Viviana
Iarussi, Emmanuel
Computer Vision and Pattern Recognition
Machine Learning
Image and Video Processing
Anatomical trees are critical for clinical diagnosis and treatment planning, yet their complex and diverse geometry make accurate representation a significant challenge. Motivated by the latest advances in large language models, we introduce an autoregressive method for synthesizing anatomical trees. Our approach first embeds vessel structures into a learned discrete vocabulary using a VQ-VAE architecture, then models their generation autoregressively with a GPT-2 model. This method effectively captures intricate geometries and branching patterns, enabling realistic vascular tree synthesis. Comprehensive qualitative and quantitative evaluations reveal that our technique achieves high-fidelity tree reconstruction with compact discrete representations. Moreover, our B-spline representation of vessel cross-sections preserves critical morphological details that are often overlooked in previous' methods parameterizations. To the best of our knowledge, this work is the first to generate blood vessels in an autoregressive manner. Code is available at https://github.com/LIA-DiTella/VesselGPT-MICCAI.
title VesselGPT: Autoregressive Modeling of Vascular Geometry
topic Computer Vision and Pattern Recognition
Machine Learning
Image and Video Processing
url https://arxiv.org/abs/2505.13318