ReBaCCA-ss: Relevance-Balanced Continuum Correlation Analysis with Smoothing and Surrogating for Quantifying Similarity Between Population Spiking Activities
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arXiv
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| Autores principales: | , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| _version_ | 1866910955410030592 |
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| author | Zhang, Xiang Xu, Chenlin Lu, Zhouxiao Wang, Haonan Song, Dong |
| author_facet | Zhang, Xiang Xu, Chenlin Lu, Zhouxiao Wang, Haonan Song, Dong |
| contents | Quantifying similarity between population spike patterns is essential for understanding how neural dynamics encode information. Traditional approaches, which combine kernel smoothing, PCA, and CCA, have limitations: smoothing kernel bandwidths are often empirically chosen, CCA maximizes alignment between patterns without considering the variance explained within patterns, and baseline correlations from stochastic spiking are rarely corrected. We introduce ReBaCCA-ss (Relevance-Balanced Continuum Correlation Analysis with smoothing and surrogating), a novel framework that addresses these challenges through three innovations: (1) balancing alignment and variance explanation via continuum canonical correlation; (2) correcting for noise using surrogate spike trains; and (3) selecting the optimal kernel bandwidth by maximizing the difference between true and surrogate correlations. ReBaCCA-ss is validated on both simulated data and hippocampal recordings from rats performing a Delayed Nonmatch-to-Sample task. It reliably identifies spatio-temporal similarities between spike patterns. Combined with Multidimensional Scaling, ReBaCCA-ss reveals structured neural representations across trials, events, sessions, and animals, offering a powerful tool for neural population analysis. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2505_13748 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | ReBaCCA-ss: Relevance-Balanced Continuum Correlation Analysis with Smoothing and Surrogating for Quantifying Similarity Between Population Spiking Activities Zhang, Xiang Xu, Chenlin Lu, Zhouxiao Wang, Haonan Song, Dong Neurons and Cognition Quantitative Methods Quantifying similarity between population spike patterns is essential for understanding how neural dynamics encode information. Traditional approaches, which combine kernel smoothing, PCA, and CCA, have limitations: smoothing kernel bandwidths are often empirically chosen, CCA maximizes alignment between patterns without considering the variance explained within patterns, and baseline correlations from stochastic spiking are rarely corrected. We introduce ReBaCCA-ss (Relevance-Balanced Continuum Correlation Analysis with smoothing and surrogating), a novel framework that addresses these challenges through three innovations: (1) balancing alignment and variance explanation via continuum canonical correlation; (2) correcting for noise using surrogate spike trains; and (3) selecting the optimal kernel bandwidth by maximizing the difference between true and surrogate correlations. ReBaCCA-ss is validated on both simulated data and hippocampal recordings from rats performing a Delayed Nonmatch-to-Sample task. It reliably identifies spatio-temporal similarities between spike patterns. Combined with Multidimensional Scaling, ReBaCCA-ss reveals structured neural representations across trials, events, sessions, and animals, offering a powerful tool for neural population analysis. |
| title | ReBaCCA-ss: Relevance-Balanced Continuum Correlation Analysis with Smoothing and Surrogating for Quantifying Similarity Between Population Spiking Activities |
| topic | Neurons and Cognition Quantitative Methods |
| url | https://arxiv.org/abs/2505.13748 |