HR-VILAGE-3K3M: A Human Respiratory Viral Immunization Longitudinal Gene Expression Dataset for Systems Immunity
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866916069410603008 |
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| author | Sun, Xuejun Song, Yiran Zhou, Xiaochen Cai, Ruilie Zhang, Yu Li, Xinyi Peng, Rui Xie, Jialiu Yan, Yuanyuan Tang, Muyao Lakshmanane, Prem Zou, Baiming Hagood, James S. Pickles, Raymond J. Li, Didong Zou, Fei Zheng, Xiaojing |
| author_facet | Sun, Xuejun Song, Yiran Zhou, Xiaochen Cai, Ruilie Zhang, Yu Li, Xinyi Peng, Rui Xie, Jialiu Yan, Yuanyuan Tang, Muyao Lakshmanane, Prem Zou, Baiming Hagood, James S. Pickles, Raymond J. Li, Didong Zou, Fei Zheng, Xiaojing |
| contents | Respiratory viral infections pose a global health burden, yet the cellular immune mechanisms underlying protection and pathology remain unclear. Natural infection cohorts often lack pre-exposure baselines and time-controlled sampling, whereas inoculation and vaccination trials generate well-structured longitudinal transcriptomic data. However, these datasets are scattered across repositories and processed inconsistently, hindering integrative and AI-driven analyses. To address these challenges, we developed the Human Respiratory Viral Immunization LongitudinAl Gene Expression (HR-VILAGE-3K3M) repository: an AI-ready resource integrating bulk and single-cell transcriptomic profiles from 3,178 subjects across 66 studies. The dataset spans vaccination, inoculation, and mixed exposures, with samples from blood and nasal swabs collected from public repositories including GEO, ImmPort, and ArrayExpress. We curated and harmonized subject-level metadata, standardized outcome measures, and applied unified preprocessing with rigorous quality control. We further provide benchmark analyses illustrating its utility. This resource supports discovery of biomarkers, immune mechanisms, and methodological development. As one of the largest longitudinal transcriptomic resources for human respiratory viral immunization, HR-VILAGE-3K3M enables reproducible and scalable analyses to accelerate vaccine and antiviral research. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2505_14725 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | HR-VILAGE-3K3M: A Human Respiratory Viral Immunization Longitudinal Gene Expression Dataset for Systems Immunity Sun, Xuejun Song, Yiran Zhou, Xiaochen Cai, Ruilie Zhang, Yu Li, Xinyi Peng, Rui Xie, Jialiu Yan, Yuanyuan Tang, Muyao Lakshmanane, Prem Zou, Baiming Hagood, James S. Pickles, Raymond J. Li, Didong Zou, Fei Zheng, Xiaojing Genomics Machine Learning Applications Respiratory viral infections pose a global health burden, yet the cellular immune mechanisms underlying protection and pathology remain unclear. Natural infection cohorts often lack pre-exposure baselines and time-controlled sampling, whereas inoculation and vaccination trials generate well-structured longitudinal transcriptomic data. However, these datasets are scattered across repositories and processed inconsistently, hindering integrative and AI-driven analyses. To address these challenges, we developed the Human Respiratory Viral Immunization LongitudinAl Gene Expression (HR-VILAGE-3K3M) repository: an AI-ready resource integrating bulk and single-cell transcriptomic profiles from 3,178 subjects across 66 studies. The dataset spans vaccination, inoculation, and mixed exposures, with samples from blood and nasal swabs collected from public repositories including GEO, ImmPort, and ArrayExpress. We curated and harmonized subject-level metadata, standardized outcome measures, and applied unified preprocessing with rigorous quality control. We further provide benchmark analyses illustrating its utility. This resource supports discovery of biomarkers, immune mechanisms, and methodological development. As one of the largest longitudinal transcriptomic resources for human respiratory viral immunization, HR-VILAGE-3K3M enables reproducible and scalable analyses to accelerate vaccine and antiviral research. |
| title | HR-VILAGE-3K3M: A Human Respiratory Viral Immunization Longitudinal Gene Expression Dataset for Systems Immunity |
| topic | Genomics Machine Learning Applications |
| url | https://arxiv.org/abs/2505.14725 |