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Main Authors: Matas, Iván, Serrano, Carmen, Nogales, Miguel, Moreno, David, Ferrándiz, Lara, Ojeda, Teresa, Acha, Begoña
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2505.16773
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author Matas, Iván
Serrano, Carmen
Nogales, Miguel
Moreno, David
Ferrándiz, Lara
Ojeda, Teresa
Acha, Begoña
author_facet Matas, Iván
Serrano, Carmen
Nogales, Miguel
Moreno, David
Ferrándiz, Lara
Ojeda, Teresa
Acha, Begoña
contents Deep learning has transformed computer vision but relies heavily on large labeled datasets and computational resources. Transfer learning, particularly fine-tuning pretrained models, offers a practical alternative; however, models pretrained on natural image datasets such as ImageNet may fail to capture domain-specific characteristics in medical imaging. This study introduces an unsupervised learning framework that extracts high-value dermatological features instead of relying solely on ImageNet-based pretraining. We employ a Variational Autoencoder (VAE) trained from scratch on a proprietary dermatological dataset, allowing the model to learn a structured and clinically relevant latent space. This self-supervised feature extractor is then compared to an ImageNet-pretrained backbone under identical classification conditions, highlighting the trade-offs between general-purpose and domain-specific pretraining. Our results reveal distinct learning patterns. The self-supervised model achieves a final validation loss of 0.110 (-33.33%), while the ImageNet-pretrained model stagnates at 0.100 (-16.67%), indicating overfitting. Accuracy trends confirm this: the self-supervised model improves from 45% to 65% (+44.44%) with a near-zero overfitting gap, whereas the ImageNet-pretrained model reaches 87% (+50.00%) but plateaus at 75% (+19.05%), with its overfitting gap increasing to +0.060. These findings suggest that while ImageNet pretraining accelerates convergence, it also amplifies overfitting on non-clinically relevant features. In contrast, self-supervised learning achieves steady improvements, stronger generalization, and superior adaptability, underscoring the importance of domain-specific feature extraction in medical imaging.
format Preprint
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institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Mitigating Overfitting in Medical Imaging: Self-Supervised Pretraining vs. ImageNet Transfer Learning for Dermatological Diagnosis
Matas, Iván
Serrano, Carmen
Nogales, Miguel
Moreno, David
Ferrándiz, Lara
Ojeda, Teresa
Acha, Begoña
Computer Vision and Pattern Recognition
Artificial Intelligence
Deep learning has transformed computer vision but relies heavily on large labeled datasets and computational resources. Transfer learning, particularly fine-tuning pretrained models, offers a practical alternative; however, models pretrained on natural image datasets such as ImageNet may fail to capture domain-specific characteristics in medical imaging. This study introduces an unsupervised learning framework that extracts high-value dermatological features instead of relying solely on ImageNet-based pretraining. We employ a Variational Autoencoder (VAE) trained from scratch on a proprietary dermatological dataset, allowing the model to learn a structured and clinically relevant latent space. This self-supervised feature extractor is then compared to an ImageNet-pretrained backbone under identical classification conditions, highlighting the trade-offs between general-purpose and domain-specific pretraining. Our results reveal distinct learning patterns. The self-supervised model achieves a final validation loss of 0.110 (-33.33%), while the ImageNet-pretrained model stagnates at 0.100 (-16.67%), indicating overfitting. Accuracy trends confirm this: the self-supervised model improves from 45% to 65% (+44.44%) with a near-zero overfitting gap, whereas the ImageNet-pretrained model reaches 87% (+50.00%) but plateaus at 75% (+19.05%), with its overfitting gap increasing to +0.060. These findings suggest that while ImageNet pretraining accelerates convergence, it also amplifies overfitting on non-clinically relevant features. In contrast, self-supervised learning achieves steady improvements, stronger generalization, and superior adaptability, underscoring the importance of domain-specific feature extraction in medical imaging.
title Mitigating Overfitting in Medical Imaging: Self-Supervised Pretraining vs. ImageNet Transfer Learning for Dermatological Diagnosis
topic Computer Vision and Pattern Recognition
Artificial Intelligence
url https://arxiv.org/abs/2505.16773