Acceleration of enzymatic reaction-diffusion kinetics by intermediate state
Fuente:
arXiv
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Preprint |
| Publicado: |
2025
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866910964046102528 |
|---|---|
| author | Fukuda, Akihiro Nakayama, Yohei Toyabe, Shoichi |
| author_facet | Fukuda, Akihiro Nakayama, Yohei Toyabe, Shoichi |
| contents | Biological molecular motors are high-performance nanomachines that convert chemical energy into mechanical motion via chemomechanical coupling. Their reaction cycles typically comprise a series of intermediate chemical states between the initial and final primary states. However, the influence of these intermediate states on motor performance has not yet been fully explored. In this study, we investigate the impact of intermediate states on the motor kinetics using a reaction-diffusion model. In most cases, the intermediate states accelerate the motor by lowering the effective barrier height. This acceleration is particularly pronounced when an external load is applied to the motor, implying the practical importance of the intermediate states. The intermediate states can also slow down the reaction in some cases, such as the slow reaction limit with asymmetric kinetics. Our findings provide practical insights into the design principles behind the high performance of biological molecular motors, as well as the development of efficient artificial molecular motors. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2505_17130 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Acceleration of enzymatic reaction-diffusion kinetics by intermediate state Fukuda, Akihiro Nakayama, Yohei Toyabe, Shoichi Biological Physics Statistical Mechanics Biological molecular motors are high-performance nanomachines that convert chemical energy into mechanical motion via chemomechanical coupling. Their reaction cycles typically comprise a series of intermediate chemical states between the initial and final primary states. However, the influence of these intermediate states on motor performance has not yet been fully explored. In this study, we investigate the impact of intermediate states on the motor kinetics using a reaction-diffusion model. In most cases, the intermediate states accelerate the motor by lowering the effective barrier height. This acceleration is particularly pronounced when an external load is applied to the motor, implying the practical importance of the intermediate states. The intermediate states can also slow down the reaction in some cases, such as the slow reaction limit with asymmetric kinetics. Our findings provide practical insights into the design principles behind the high performance of biological molecular motors, as well as the development of efficient artificial molecular motors. |
| title | Acceleration of enzymatic reaction-diffusion kinetics by intermediate state |
| topic | Biological Physics Statistical Mechanics |
| url | https://arxiv.org/abs/2505.17130 |