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Auteurs principaux: Wu, Skyler, Yang, Shihao, Kou, S. C.
Format: Preprint
Publié: 2025
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Accès en ligne:https://arxiv.org/abs/2505.21723
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author Wu, Skyler
Yang, Shihao
Kou, S. C.
author_facet Wu, Skyler
Yang, Shihao
Kou, S. C.
contents In the era of AI, neural networks have become increasingly popular for modeling, inference, and prediction, largely due to their potential for universal approximation. With the proliferation of such deep learning models, a question arises: are leaner statistical methods still relevant? To shed insight on this question, we employ the mechanistic nonlinear ordinary differential equation (ODE) inverse problem as a testbed, using the physics-informed neural network (PINN) as a representative of the deep learning paradigm and manifold-constrained Gaussian process inference (MAGI) as a representative of statistically principled methods. Through case studies involving the SEIR model from epidemiology and the Lorenz model from chaotic dynamics, we demonstrate that statistical methods are far from obsolete, especially when working with sparse and noisy observations. On tasks such as parameter inference and trajectory reconstruction, statistically principled methods consistently achieve lower bias and variance, while using far fewer parameters and requiring less hyperparameter tuning. Statistical methods can also decisively outperform deep learning models on out-of-sample future prediction, where the absence of relevant data often leads overparameterized models astray. Additionally, we find that statistically principled approaches are more robust to accumulation of numerical imprecision and can represent the underlying system more faithfully to the true governing ODEs.
format Preprint
id arxiv_https___arxiv_org_abs_2505_21723
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Are Statistical Methods Obsolete in the Era of Deep Learning? A Study of ODE Inverse Problems
Wu, Skyler
Yang, Shihao
Kou, S. C.
Computation
Machine Learning
In the era of AI, neural networks have become increasingly popular for modeling, inference, and prediction, largely due to their potential for universal approximation. With the proliferation of such deep learning models, a question arises: are leaner statistical methods still relevant? To shed insight on this question, we employ the mechanistic nonlinear ordinary differential equation (ODE) inverse problem as a testbed, using the physics-informed neural network (PINN) as a representative of the deep learning paradigm and manifold-constrained Gaussian process inference (MAGI) as a representative of statistically principled methods. Through case studies involving the SEIR model from epidemiology and the Lorenz model from chaotic dynamics, we demonstrate that statistical methods are far from obsolete, especially when working with sparse and noisy observations. On tasks such as parameter inference and trajectory reconstruction, statistically principled methods consistently achieve lower bias and variance, while using far fewer parameters and requiring less hyperparameter tuning. Statistical methods can also decisively outperform deep learning models on out-of-sample future prediction, where the absence of relevant data often leads overparameterized models astray. Additionally, we find that statistically principled approaches are more robust to accumulation of numerical imprecision and can represent the underlying system more faithfully to the true governing ODEs.
title Are Statistical Methods Obsolete in the Era of Deep Learning? A Study of ODE Inverse Problems
topic Computation
Machine Learning
url https://arxiv.org/abs/2505.21723