Chemotaxis of branched cells in complex environments
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arXiv
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| Main Authors: | , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866916766863589376 |
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| author | Liu, Jiayi Ron, Jonathan E. Rinaldi, Giulia Williantarra, Ivanna Georgantzoglou, Antonios de Vries, Ingrid Sixt, Michael Sarris, Milka Gov, Nir S. |
| author_facet | Liu, Jiayi Ron, Jonathan E. Rinaldi, Giulia Williantarra, Ivanna Georgantzoglou, Antonios de Vries, Ingrid Sixt, Michael Sarris, Milka Gov, Nir S. |
| contents | Cell migration in vivo is often guided by chemical signals. Such chemotaxis, such as performed by immune cells migrating to a wound site, is complicated by the complex geometry inside living tissues. In this study, we extend our theoretical model of branched-cell migration on a network by introducing chemokine sources to explore the cellular response. The model predicts a speed-accuracy tradeoff, whereby slow cells are significantly more accurate and able to follow efficiently a weak chemoattractant signal. We then compare the model's predictions with experimental observations of neutrophils migrating to the site of laser-inflicted wound in a zebrafish larva fin, and migrating in-vitro inside a regular lattice of pillars. We find that the model captures the details of the sub-cellular response to the chemokine gradient, as well as the large-scale migration response. This comparison suggests that the neutrophils behave as fast cells, compromising their chemotaxis accuracy, which explains the functionality of these immune cells. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2505_21949 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Chemotaxis of branched cells in complex environments Liu, Jiayi Ron, Jonathan E. Rinaldi, Giulia Williantarra, Ivanna Georgantzoglou, Antonios de Vries, Ingrid Sixt, Michael Sarris, Milka Gov, Nir S. Biological Physics Cell Behavior Cell migration in vivo is often guided by chemical signals. Such chemotaxis, such as performed by immune cells migrating to a wound site, is complicated by the complex geometry inside living tissues. In this study, we extend our theoretical model of branched-cell migration on a network by introducing chemokine sources to explore the cellular response. The model predicts a speed-accuracy tradeoff, whereby slow cells are significantly more accurate and able to follow efficiently a weak chemoattractant signal. We then compare the model's predictions with experimental observations of neutrophils migrating to the site of laser-inflicted wound in a zebrafish larva fin, and migrating in-vitro inside a regular lattice of pillars. We find that the model captures the details of the sub-cellular response to the chemokine gradient, as well as the large-scale migration response. This comparison suggests that the neutrophils behave as fast cells, compromising their chemotaxis accuracy, which explains the functionality of these immune cells. |
| title | Chemotaxis of branched cells in complex environments |
| topic | Biological Physics Cell Behavior |
| url | https://arxiv.org/abs/2505.21949 |