Softness and Hydrodynamic Interactions Regulate Lipoprotein Transport in Crowded Yolk Environments
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arXiv
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| Format: | Preprint |
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2025
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| _version_ | 1866913864212283392 |
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| author | Anthuparambil, Nimmi Das Dargasz, Michelle Timmermann, Sonja Girelli, Anita Retzbach, Sebastian Möller, Johannes Jo, Wonhyuk Raza, Agha Mohammad Leonau, Aliaksandr Wrigley, James Unger, Frederik Bin, Maddalena Rajaiah, Prince Prabhu Andronis, Iason Chèvremont, William Hallmann, Jörg Rodriguez-Fernandez, Angel Pudell, Jan-Etienne Brausse, Felix Boesenberg, Ulrike Youssef, Mohamed Shayduk, Roman Rysov, Rustam Madsen, Anders Lehmkühler, Felix Paulus, Michael Zhang, Fajun Perakis, Fivos Schreiber, Frank Gutt, Christian |
| author_facet | Anthuparambil, Nimmi Das Dargasz, Michelle Timmermann, Sonja Girelli, Anita Retzbach, Sebastian Möller, Johannes Jo, Wonhyuk Raza, Agha Mohammad Leonau, Aliaksandr Wrigley, James Unger, Frederik Bin, Maddalena Rajaiah, Prince Prabhu Andronis, Iason Chèvremont, William Hallmann, Jörg Rodriguez-Fernandez, Angel Pudell, Jan-Etienne Brausse, Felix Boesenberg, Ulrike Youssef, Mohamed Shayduk, Roman Rysov, Rustam Madsen, Anders Lehmkühler, Felix Paulus, Michael Zhang, Fajun Perakis, Fivos Schreiber, Frank Gutt, Christian |
| contents | Low-density lipoproteins (LDLs) serve as nutrient reservoirs in egg yolk for embryonic development and as promising drug carriers. Both roles critically depend on their mobility in densely crowded biological environments. Under these crowded conditions, diffusion is hindered by transient confinement within dynamic cages formed by neighboring particles, driven by solvent-mediated hydrodynamic interactions and memory effects -- phenomena that have remained challenging to characterize computationally and experimentally. Here, we employ megahertz X-ray photon correlation spectroscopy to directly probe the cage dynamics of LDLs in yolk-plasma across various concentrations. We find that LDLs undergo anomalous diffusion, experiencing $\approx$ 100-fold reduction in self-diffusion at high concentrations compared to dilute solutions. This drastic slowing-down is attributed to a combination of hydrodynamic interactions, direct particle-particle interactions, and the inherent softness of LDL particles. Despite reduced dynamics, yolk-plasma remains as a liquid, yet sluggish, balancing dense packing, structural stability, and fluidity essential for controlled lipid release during embryogenesis. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2505_22520 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Softness and Hydrodynamic Interactions Regulate Lipoprotein Transport in Crowded Yolk Environments Anthuparambil, Nimmi Das Dargasz, Michelle Timmermann, Sonja Girelli, Anita Retzbach, Sebastian Möller, Johannes Jo, Wonhyuk Raza, Agha Mohammad Leonau, Aliaksandr Wrigley, James Unger, Frederik Bin, Maddalena Rajaiah, Prince Prabhu Andronis, Iason Chèvremont, William Hallmann, Jörg Rodriguez-Fernandez, Angel Pudell, Jan-Etienne Brausse, Felix Boesenberg, Ulrike Youssef, Mohamed Shayduk, Roman Rysov, Rustam Madsen, Anders Lehmkühler, Felix Paulus, Michael Zhang, Fajun Perakis, Fivos Schreiber, Frank Gutt, Christian Soft Condensed Matter Low-density lipoproteins (LDLs) serve as nutrient reservoirs in egg yolk for embryonic development and as promising drug carriers. Both roles critically depend on their mobility in densely crowded biological environments. Under these crowded conditions, diffusion is hindered by transient confinement within dynamic cages formed by neighboring particles, driven by solvent-mediated hydrodynamic interactions and memory effects -- phenomena that have remained challenging to characterize computationally and experimentally. Here, we employ megahertz X-ray photon correlation spectroscopy to directly probe the cage dynamics of LDLs in yolk-plasma across various concentrations. We find that LDLs undergo anomalous diffusion, experiencing $\approx$ 100-fold reduction in self-diffusion at high concentrations compared to dilute solutions. This drastic slowing-down is attributed to a combination of hydrodynamic interactions, direct particle-particle interactions, and the inherent softness of LDL particles. Despite reduced dynamics, yolk-plasma remains as a liquid, yet sluggish, balancing dense packing, structural stability, and fluidity essential for controlled lipid release during embryogenesis. |
| title | Softness and Hydrodynamic Interactions Regulate Lipoprotein Transport in Crowded Yolk Environments |
| topic | Soft Condensed Matter |
| url | https://arxiv.org/abs/2505.22520 |