DSAGL: Dual-Stream Attention-Guided Learning for Weakly Supervised Whole Slide Image Classification

Fuente: arXiv
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Autori principali: Cao, Daoxi, Cheng, Hangbei, Li, Yijin, Zhou, Ruolin, Zhang, Xuehan, Li, Xinyi, Li, Binwei, Gu, Xuancheng, Zhang, Jianan, Liu, Xueyu, Wu, Yongfei
Natura: Preprint
Pubblicazione: 2025
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author Cao, Daoxi
Cheng, Hangbei
Li, Yijin
Zhou, Ruolin
Zhang, Xuehan
Li, Xinyi
Li, Binwei
Gu, Xuancheng
Zhang, Jianan
Liu, Xueyu
Wu, Yongfei
author_facet Cao, Daoxi
Cheng, Hangbei
Li, Yijin
Zhou, Ruolin
Zhang, Xuehan
Li, Xinyi
Li, Binwei
Gu, Xuancheng
Zhang, Jianan
Liu, Xueyu
Wu, Yongfei
contents Whole-slide images (WSIs) are critical for cancer diagnosis due to their ultra-high resolution and rich semantic content. However, their massive size and the limited availability of fine-grained annotations pose substantial challenges for conventional supervised learning. We propose DSAGL (Dual-Stream Attention-Guided Learning), a novel weakly supervised classification framework that combines a teacher-student architecture with a dual-stream design. DSAGL explicitly addresses instance-level ambiguity and bag-level semantic consistency by generating multi-scale attention-based pseudo labels and guiding instance-level learning. A shared lightweight encoder (VSSMamba) enables efficient long-range dependency modeling, while a fusion-attentive module (FASA) enhances focus on sparse but diagnostically relevant regions. We further introduce a hybrid loss to enforce mutual consistency between the two streams. Experiments on CIFAR-10, NCT-CRC, and TCGA-Lung datasets demonstrate that DSAGL consistently outperforms state-of-the-art MIL baselines, achieving superior discriminative performance and robustness under weak supervision.
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id arxiv_https___arxiv_org_abs_2505_23341
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle DSAGL: Dual-Stream Attention-Guided Learning for Weakly Supervised Whole Slide Image Classification
Cao, Daoxi
Cheng, Hangbei
Li, Yijin
Zhou, Ruolin
Zhang, Xuehan
Li, Xinyi
Li, Binwei
Gu, Xuancheng
Zhang, Jianan
Liu, Xueyu
Wu, Yongfei
Computer Vision and Pattern Recognition
Whole-slide images (WSIs) are critical for cancer diagnosis due to their ultra-high resolution and rich semantic content. However, their massive size and the limited availability of fine-grained annotations pose substantial challenges for conventional supervised learning. We propose DSAGL (Dual-Stream Attention-Guided Learning), a novel weakly supervised classification framework that combines a teacher-student architecture with a dual-stream design. DSAGL explicitly addresses instance-level ambiguity and bag-level semantic consistency by generating multi-scale attention-based pseudo labels and guiding instance-level learning. A shared lightweight encoder (VSSMamba) enables efficient long-range dependency modeling, while a fusion-attentive module (FASA) enhances focus on sparse but diagnostically relevant regions. We further introduce a hybrid loss to enforce mutual consistency between the two streams. Experiments on CIFAR-10, NCT-CRC, and TCGA-Lung datasets demonstrate that DSAGL consistently outperforms state-of-the-art MIL baselines, achieving superior discriminative performance and robustness under weak supervision.
title DSAGL: Dual-Stream Attention-Guided Learning for Weakly Supervised Whole Slide Image Classification
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2505.23341