Nanoelectrospray ionization coupled to a linear charge detection array ion trap spectrometer for single viral particles analysis
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arXiv
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| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| author | Maclot, S. Reinert, T. Duplantier, L. Montagne, G. Clavier, C. Dagany, X. Comby-Zerbino, C. Kerleroux, M. Thiede, L. Pogan, R. Uetrecht, C. Kozhinov, A. N. Nagornov, K. O. Tsybin, Y. O. Papanastasiou, D. Antoine, R. |
| author_facet | Maclot, S. Reinert, T. Duplantier, L. Montagne, G. Clavier, C. Dagany, X. Comby-Zerbino, C. Kerleroux, M. Thiede, L. Pogan, R. Uetrecht, C. Kozhinov, A. N. Nagornov, K. O. Tsybin, Y. O. Papanastasiou, D. Antoine, R. |
| contents | This work presents the implementation of a new charge detection mass spectrometer (CDMS) design that operates in a stand-alone mode, thanks to its integration with nanoelectrospray ionization. More specifically, this innovative CDMS consists of a linear charge detection array ion trap spectrometer that combines an eight-tube detector array with conical electrodes. This configuration allows for recording data in both transmission mode (linear array) and ion trapping mode (ConeArrayTrap), which enables the measurement of time-of-flight (related to the mass-to-charge ratio) along with the charge of individual ions. As a result, this design supports high-throughput metrology of viruses at the single-particle level. The devices and geometry of the instrument have been developed based on ion optics simulations. The performance of the current instrument is demonstrated using human norovirus-like particles (hNoVLP) and Adenovirus Ad(5) (hAdV5). |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2506_01593 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Nanoelectrospray ionization coupled to a linear charge detection array ion trap spectrometer for single viral particles analysis Maclot, S. Reinert, T. Duplantier, L. Montagne, G. Clavier, C. Dagany, X. Comby-Zerbino, C. Kerleroux, M. Thiede, L. Pogan, R. Uetrecht, C. Kozhinov, A. N. Nagornov, K. O. Tsybin, Y. O. Papanastasiou, D. Antoine, R. Instrumentation and Detectors Biological Physics Chemical Physics This work presents the implementation of a new charge detection mass spectrometer (CDMS) design that operates in a stand-alone mode, thanks to its integration with nanoelectrospray ionization. More specifically, this innovative CDMS consists of a linear charge detection array ion trap spectrometer that combines an eight-tube detector array with conical electrodes. This configuration allows for recording data in both transmission mode (linear array) and ion trapping mode (ConeArrayTrap), which enables the measurement of time-of-flight (related to the mass-to-charge ratio) along with the charge of individual ions. As a result, this design supports high-throughput metrology of viruses at the single-particle level. The devices and geometry of the instrument have been developed based on ion optics simulations. The performance of the current instrument is demonstrated using human norovirus-like particles (hNoVLP) and Adenovirus Ad(5) (hAdV5). |
| title | Nanoelectrospray ionization coupled to a linear charge detection array ion trap spectrometer for single viral particles analysis |
| topic | Instrumentation and Detectors Biological Physics Chemical Physics |
| url | https://arxiv.org/abs/2506.01593 |