Alzheimers Disease Classification in Functional MRI With 4D Joint Temporal-Spatial Kernels in Novel 4D CNN Model

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Hauptverfasser: Cavazos, Javier Salazar, Peltier, Scott
Format: Preprint
Veröffentlicht: 2025
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author Cavazos, Javier Salazar
Peltier, Scott
author_facet Cavazos, Javier Salazar
Peltier, Scott
contents Previous works in the literature apply 3D spatial-only models on 4D functional MRI data leading to possible sub-par feature extraction to be used for downstream tasks like classification. In this work, we aim to develop a novel 4D convolution network to extract 4D joint temporal-spatial kernels that not only learn spatial information but in addition also capture temporal dynamics. Experimental results show promising performance in capturing spatial-temporal data in functional MRI compared to 3D models. The 4D CNN model improves Alzheimers disease diagnosis for rs-fMRI data, enabling earlier detection and better interventions. Future research could explore task-based fMRI applications and regression tasks, enhancing understanding of cognitive performance and disease progression.
format Preprint
id arxiv_https___arxiv_org_abs_2506_02060
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Alzheimers Disease Classification in Functional MRI With 4D Joint Temporal-Spatial Kernels in Novel 4D CNN Model
Cavazos, Javier Salazar
Peltier, Scott
Image and Video Processing
Computer Vision and Pattern Recognition
Previous works in the literature apply 3D spatial-only models on 4D functional MRI data leading to possible sub-par feature extraction to be used for downstream tasks like classification. In this work, we aim to develop a novel 4D convolution network to extract 4D joint temporal-spatial kernels that not only learn spatial information but in addition also capture temporal dynamics. Experimental results show promising performance in capturing spatial-temporal data in functional MRI compared to 3D models. The 4D CNN model improves Alzheimers disease diagnosis for rs-fMRI data, enabling earlier detection and better interventions. Future research could explore task-based fMRI applications and regression tasks, enhancing understanding of cognitive performance and disease progression.
title Alzheimers Disease Classification in Functional MRI With 4D Joint Temporal-Spatial Kernels in Novel 4D CNN Model
topic Image and Video Processing
Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2506.02060