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Bibliographic Details
Main Authors: Lin, Shiangyi, Lan, Hui, Syrgkanis, Vasilis
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2506.02200
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author Lin, Shiangyi
Lan, Hui
Syrgkanis, Vasilis
author_facet Lin, Shiangyi
Lan, Hui
Syrgkanis, Vasilis
contents Traditional instrumental variable (IV) estimators face a fundamental constraint: they can only accommodate as many endogenous treatment variables as available instruments. This limitation becomes particularly challenging in settings where the treatment is presented in a high-dimensional and unstructured manner (e.g. descriptions of patient treatment pathways in a hospital). In such settings, researchers typically resort to applying unsupervised dimension reduction techniques to learn a low-dimensional treatment representation prior to implementing IV regression analysis. We show that such methods can suffer from substantial omitted variable bias due to implicit regularization in the representation learning step. We propose a novel approach to construct treatment representations by explicitly incorporating instrumental variables during the representation learning process. Our approach provides a framework for handling high-dimensional endogenous variables with limited instruments. We demonstrate both theoretically and empirically that fitting IV models on these instrument-informed representations ensures identification of directions that optimize outcome prediction. Our experiments show that our proposed methodology improves upon the conventional two-stage approaches that perform dimension reduction without incorporating instrument information.
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institution arXiv
publishDate 2025
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spellingShingle Learning Treatment Representations for Downstream Instrumental Variable Regression
Lin, Shiangyi
Lan, Hui
Syrgkanis, Vasilis
Machine Learning
Methodology
Traditional instrumental variable (IV) estimators face a fundamental constraint: they can only accommodate as many endogenous treatment variables as available instruments. This limitation becomes particularly challenging in settings where the treatment is presented in a high-dimensional and unstructured manner (e.g. descriptions of patient treatment pathways in a hospital). In such settings, researchers typically resort to applying unsupervised dimension reduction techniques to learn a low-dimensional treatment representation prior to implementing IV regression analysis. We show that such methods can suffer from substantial omitted variable bias due to implicit regularization in the representation learning step. We propose a novel approach to construct treatment representations by explicitly incorporating instrumental variables during the representation learning process. Our approach provides a framework for handling high-dimensional endogenous variables with limited instruments. We demonstrate both theoretically and empirically that fitting IV models on these instrument-informed representations ensures identification of directions that optimize outcome prediction. Our experiments show that our proposed methodology improves upon the conventional two-stage approaches that perform dimension reduction without incorporating instrument information.
title Learning Treatment Representations for Downstream Instrumental Variable Regression
topic Machine Learning
Methodology
url https://arxiv.org/abs/2506.02200