Dynamics of Wound Closure in Living Nematic Epithelia
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arXiv
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| Format: | Preprint |
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2025
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| author | Andralojc, Henry Turley, Jake Weavers, Helen Martin, Paul Chenchiah, Isaac V. Bennett, Rachel R. Liverpool, Tanniemola B. |
| author_facet | Andralojc, Henry Turley, Jake Weavers, Helen Martin, Paul Chenchiah, Isaac V. Bennett, Rachel R. Liverpool, Tanniemola B. |
| contents | We study theoretically the closure of a wound in a layer of epithelial cells in a living tissue after damage. Our analysis is informed by our recent experiments observing re-epithelialisation in vivo of Drosophila pupae. On time and length-scales such that the evolution of the epithelial tissue near the wound is well captured by that of a 2D active fluid with local nematic order, we consider the free-surface problem of a hole in a bounded region of tissue, and study the role that active stresses far from the hole play in the closure of the hole. For parallel anchored nematic order at the wound boundary (as we observe in our experiments), we find that closure is accelerated when the active stresses are contractile and slowed down when the stresses are extensile. Parallel anchoring also leads to the appearance of topological defects which annihilate upon wound closure. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2506_04922 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Dynamics of Wound Closure in Living Nematic Epithelia Andralojc, Henry Turley, Jake Weavers, Helen Martin, Paul Chenchiah, Isaac V. Bennett, Rachel R. Liverpool, Tanniemola B. Soft Condensed Matter Biological Physics We study theoretically the closure of a wound in a layer of epithelial cells in a living tissue after damage. Our analysis is informed by our recent experiments observing re-epithelialisation in vivo of Drosophila pupae. On time and length-scales such that the evolution of the epithelial tissue near the wound is well captured by that of a 2D active fluid with local nematic order, we consider the free-surface problem of a hole in a bounded region of tissue, and study the role that active stresses far from the hole play in the closure of the hole. For parallel anchored nematic order at the wound boundary (as we observe in our experiments), we find that closure is accelerated when the active stresses are contractile and slowed down when the stresses are extensile. Parallel anchoring also leads to the appearance of topological defects which annihilate upon wound closure. |
| title | Dynamics of Wound Closure in Living Nematic Epithelia |
| topic | Soft Condensed Matter Biological Physics |
| url | https://arxiv.org/abs/2506.04922 |