Noninvasive precision modulation of high-level neural population activity via natural vision perturbations
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arXiv
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| Autori principali: | , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| _version_ | 1866908407653466112 |
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| author | Gaziv, Guy Goulding, Sarah Ayvazian-Hancock, Ani Bai, Yoon DiCarlo, James J. |
| author_facet | Gaziv, Guy Goulding, Sarah Ayvazian-Hancock, Ani Bai, Yoon DiCarlo, James J. |
| contents | Precise control of neural activity -- modulating target neurons deep in the brain while leaving nearby neurons unaffected -- is an outstanding challenge in neuroscience, generally approached using invasive techniques. This study investigates the possibility of precisely and noninvasively modulating neural activity in the high-level primate ventral visual stream via perturbations on one's natural visual feed. When tested on macaque inferior temporal (IT) neural populations, we found quantitative agreement between the model-predicted and biologically realized effect: strong modulation concentrated on targeted neural sites. We extended this to demonstrate accurate injection of experimenter-chosen neural population patterns via subtle perturbations applied on the background of typical natural visual feeds. These results highlight that current machine-executable models of the ventral stream can now design noninvasive, visually-delivered, possibly imperceptible neural interventions at the resolution of individual neurons. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2506_05633 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Noninvasive precision modulation of high-level neural population activity via natural vision perturbations Gaziv, Guy Goulding, Sarah Ayvazian-Hancock, Ani Bai, Yoon DiCarlo, James J. Neurons and Cognition Computer Vision and Pattern Recognition Neural and Evolutionary Computing Precise control of neural activity -- modulating target neurons deep in the brain while leaving nearby neurons unaffected -- is an outstanding challenge in neuroscience, generally approached using invasive techniques. This study investigates the possibility of precisely and noninvasively modulating neural activity in the high-level primate ventral visual stream via perturbations on one's natural visual feed. When tested on macaque inferior temporal (IT) neural populations, we found quantitative agreement between the model-predicted and biologically realized effect: strong modulation concentrated on targeted neural sites. We extended this to demonstrate accurate injection of experimenter-chosen neural population patterns via subtle perturbations applied on the background of typical natural visual feeds. These results highlight that current machine-executable models of the ventral stream can now design noninvasive, visually-delivered, possibly imperceptible neural interventions at the resolution of individual neurons. |
| title | Noninvasive precision modulation of high-level neural population activity via natural vision perturbations |
| topic | Neurons and Cognition Computer Vision and Pattern Recognition Neural and Evolutionary Computing |
| url | https://arxiv.org/abs/2506.05633 |