First positronium imaging using $^{44}$Sc with the J-PET scanner: a case study on the NEMA-Image Quality phantom
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| Format: | Preprint |
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2025
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| _version_ | 1866917399191617536 |
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| author | Das, Manish Sharma, Sushil Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kubat, Karol Kumar, Deepak Venadan, Anoop Kunimmal Lisowski, Edward Lisowski, Filip Medrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej del Rio, Elena Perez Rädler, Martin Rominger, Axel Shi, Kuangyu Skurzok, Magdalena Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Beyene, Ermias Yitayew Stępień, Ewa Ł. Moskal, Paweł |
| author_facet | Das, Manish Sharma, Sushil Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kubat, Karol Kumar, Deepak Venadan, Anoop Kunimmal Lisowski, Edward Lisowski, Filip Medrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej del Rio, Elena Perez Rädler, Martin Rominger, Axel Shi, Kuangyu Skurzok, Magdalena Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Beyene, Ermias Yitayew Stępień, Ewa Ł. Moskal, Paweł |
| contents | Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the positronium atom. Currently, the method is under rapid development in terms of reconstruction and detection systems. Recently, the first in vivo PLI of the human brain was performed using the J-PET scanner utilizing the $^{68}$Ga isotope. However, this isotope has limitations due to its comparatively low prompt gamma yields, which is crucial for positronium lifetime measurement. Among alternative radionuclides, $^{44}$Sc stands out as a promising isotope for PLI, characterized by a clinically suitable half-life (4.04 hours) emitting 1157 keV prompt gamma in 100% cases after the emission of the positron. This study reports the first experimental demonstration of PLI with $^{44}$Sc, carried out on a NEMA-Image Quality (IQ) phantom using the Modular J-PET tomograph-the first plastic scintillators-based PET scanner. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2506_07230 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | First positronium imaging using $^{44}$Sc with the J-PET scanner: a case study on the NEMA-Image Quality phantom Das, Manish Sharma, Sushil Bilewicz, Aleksander Choiński, Jarosław Chug, Neha Curceanu, Catalina Czerwiński, Eryk Hajduga, Jakub Jalali, Sharareh Kacprzak, Krzysztof Kaplanoglu, Tevfik Kapłon, Łukasz Kasperska, Kamila Khreptak, Aleksander Korcyl, Grzegorz Kozik, Tomasz Kubat, Karol Kumar, Deepak Venadan, Anoop Kunimmal Lisowski, Edward Lisowski, Filip Medrala-Sowa, Justyna Moyo, Simbarashe Mryka, Wiktor Niedźwiecki, Szymon Pandey, Piyush Parzych, Szymon Porcelli, Alessio Rachwał, Bartłomiej del Rio, Elena Perez Rädler, Martin Rominger, Axel Shi, Kuangyu Skurzok, Magdalena Stolarz, Anna Szumlak, Tomasz Tanty, Pooja Ardebili, Keyvan Tayefi Tiwari, Satyam Eliyan, Kavya Valsan Walczak, Rafał Beyene, Ermias Yitayew Stępień, Ewa Ł. Moskal, Paweł Medical Physics Instrumentation and Detectors Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the positronium atom. Currently, the method is under rapid development in terms of reconstruction and detection systems. Recently, the first in vivo PLI of the human brain was performed using the J-PET scanner utilizing the $^{68}$Ga isotope. However, this isotope has limitations due to its comparatively low prompt gamma yields, which is crucial for positronium lifetime measurement. Among alternative radionuclides, $^{44}$Sc stands out as a promising isotope for PLI, characterized by a clinically suitable half-life (4.04 hours) emitting 1157 keV prompt gamma in 100% cases after the emission of the positron. This study reports the first experimental demonstration of PLI with $^{44}$Sc, carried out on a NEMA-Image Quality (IQ) phantom using the Modular J-PET tomograph-the first plastic scintillators-based PET scanner. |
| title | First positronium imaging using $^{44}$Sc with the J-PET scanner: a case study on the NEMA-Image Quality phantom |
| topic | Medical Physics Instrumentation and Detectors |
| url | https://arxiv.org/abs/2506.07230 |