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| Auteurs principaux: | , , , |
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| Format: | Preprint |
| Publié: |
2025
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| Accès en ligne: | https://arxiv.org/abs/2506.07365 |
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| _version_ | 1866916784959913984 |
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| author | Zhe Wang Sun, Linda Z. Chen, Cong |
| author_facet | Zhe Wang Sun, Linda Z. Chen, Cong |
| contents | Waterfall plots are a key tool in early phase oncology clinical studies for visualizing individual patients' tumor size changes and provide efficacy assessment. However, comparing waterfall plots from ongoing studies with limited follow-up to those from completed studies with long follow-up is challenging due to underestimation of tumor response in ongoing patients. To address this, we propose a novel adjustment method that projects the waterfall plot of an ongoing study to approximate its appearance with sufficient follow-up. Recognizing that waterfall plots are simply rotated survival functions of best tumor size reduction from the baseline (in percentage), we frame the problem in a survival analysis context and adjust weight of each ongoing patients in an interim look Kaplan-Meier curve by leveraging the probability of potential tumor response improvement (i.e., "censoring"). The probability of improvement is quantified through an incomplete multinomial model to estimate the best tumor size change occurrence at each scan time. The adjusted waterfall plots of experimental treatments from ongoing studies are suitable for comparison with historical controls from completed studies, without requiring individual-level data of those controls. A real-data example demonstrates the utility of this method for robust efficacy evaluations. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2506_07365 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Advancing Waterfall Plots for Cancer Treatment Response Assessment through Adjustment of Incomplete Follow-Up Time Zhe Wang Sun, Linda Z. Chen, Cong Applications Waterfall plots are a key tool in early phase oncology clinical studies for visualizing individual patients' tumor size changes and provide efficacy assessment. However, comparing waterfall plots from ongoing studies with limited follow-up to those from completed studies with long follow-up is challenging due to underestimation of tumor response in ongoing patients. To address this, we propose a novel adjustment method that projects the waterfall plot of an ongoing study to approximate its appearance with sufficient follow-up. Recognizing that waterfall plots are simply rotated survival functions of best tumor size reduction from the baseline (in percentage), we frame the problem in a survival analysis context and adjust weight of each ongoing patients in an interim look Kaplan-Meier curve by leveraging the probability of potential tumor response improvement (i.e., "censoring"). The probability of improvement is quantified through an incomplete multinomial model to estimate the best tumor size change occurrence at each scan time. The adjusted waterfall plots of experimental treatments from ongoing studies are suitable for comparison with historical controls from completed studies, without requiring individual-level data of those controls. A real-data example demonstrates the utility of this method for robust efficacy evaluations. |
| title | Advancing Waterfall Plots for Cancer Treatment Response Assessment through Adjustment of Incomplete Follow-Up Time |
| topic | Applications |
| url | https://arxiv.org/abs/2506.07365 |