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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| Soggetti: | |
| Accesso online: | https://arxiv.org/abs/2506.11522 |
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| _version_ | 1866911004583002112 |
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| author | Yang, Juanjuan Jahnke, Kevin Xin, Ling Jing, Xinxin Zhan, Pengfei Peil, Andreas Griffo, Alessandra Škugor, Marko Yang, Donglei Fan, Sisi Göpfrich, Kerstin Yan, Hao Wang, Pengfei Liu, Na |
| author_facet | Yang, Juanjuan Jahnke, Kevin Xin, Ling Jing, Xinxin Zhan, Pengfei Peil, Andreas Griffo, Alessandra Škugor, Marko Yang, Donglei Fan, Sisi Göpfrich, Kerstin Yan, Hao Wang, Pengfei Liu, Na |
| contents | Membrane morphology and its dynamic adaptation regulate many cellular functions, which are often mediated by membrane proteins. Advances in DNA nanotechnology have enabled the realization of various protein-inspired structures and functions with precise control at the nanometer level, suggesting a viable tool to artificially engineer the membrane morphology. In this work, we demonstrate a DNA origami cross (DOC) structure that can be anchored onto giant unilamellar vesicles (GUVs) and subsequently polymerized into micron-scale reconfigurable one-dimensional (1D) chains or two-dimensional (2D) lattices. Such DNA origami-based networks can be switched between left-handed (LH) and right-handed (RH) conformations by DNA fuels and exhibit potent efficacy in remodeling the membrane curvatures of GUVs. This work sheds light on designing hierarchically-assembled dynamic DNA systems for the programmable modulation of synthetic cells for useful applications. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2506_11522 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Modulating lipid membrane morphology by dynamic DNA origami networks Yang, Juanjuan Jahnke, Kevin Xin, Ling Jing, Xinxin Zhan, Pengfei Peil, Andreas Griffo, Alessandra Škugor, Marko Yang, Donglei Fan, Sisi Göpfrich, Kerstin Yan, Hao Wang, Pengfei Liu, Na Biological Physics Membrane morphology and its dynamic adaptation regulate many cellular functions, which are often mediated by membrane proteins. Advances in DNA nanotechnology have enabled the realization of various protein-inspired structures and functions with precise control at the nanometer level, suggesting a viable tool to artificially engineer the membrane morphology. In this work, we demonstrate a DNA origami cross (DOC) structure that can be anchored onto giant unilamellar vesicles (GUVs) and subsequently polymerized into micron-scale reconfigurable one-dimensional (1D) chains or two-dimensional (2D) lattices. Such DNA origami-based networks can be switched between left-handed (LH) and right-handed (RH) conformations by DNA fuels and exhibit potent efficacy in remodeling the membrane curvatures of GUVs. This work sheds light on designing hierarchically-assembled dynamic DNA systems for the programmable modulation of synthetic cells for useful applications. |
| title | Modulating lipid membrane morphology by dynamic DNA origami networks |
| topic | Biological Physics |
| url | https://arxiv.org/abs/2506.11522 |