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Main Authors: Fabbri, Francesco, Scarpolini, Martino Andrea, Iollo, Angelo, Viola, Francesco, Tudisco, Francesco
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2506.13628
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author Fabbri, Francesco
Scarpolini, Martino Andrea
Iollo, Angelo
Viola, Francesco
Tudisco, Francesco
author_facet Fabbri, Francesco
Scarpolini, Martino Andrea
Iollo, Angelo
Viola, Francesco
Tudisco, Francesco
contents Synthetic data generation plays a crucial role in medical research by mitigating privacy concerns and enabling large-scale patient data analysis. This study presents a beta-Variational Autoencoder Graph Convolutional Neural Network framework for generating synthetic Abdominal Aorta Aneurysms (AAA). Using a small real-world dataset, our approach extracts key anatomical features and captures complex statistical relationships within a compact disentangled latent space. To address data limitations, low-impact data augmentation based on Procrustes analysis was employed, preserving anatomical integrity. The generation strategies, both deterministic and stochastic, manage to enhance data diversity while ensuring realism. Compared to PCA-based approaches, our model performs more robustly on unseen data by capturing complex, nonlinear anatomical variations. This enables more comprehensive clinical and statistical analyses than the original dataset alone. The resulting synthetic AAA dataset preserves patient privacy while providing a scalable foundation for medical research, device testing, and computational modeling.
format Preprint
id arxiv_https___arxiv_org_abs_2506_13628
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Graph-Convolutional-Beta-VAE for Synthetic Abdominal Aorta Aneurysm Generation
Fabbri, Francesco
Scarpolini, Martino Andrea
Iollo, Angelo
Viola, Francesco
Tudisco, Francesco
Machine Learning
Artificial Intelligence
Tissues and Organs
Synthetic data generation plays a crucial role in medical research by mitigating privacy concerns and enabling large-scale patient data analysis. This study presents a beta-Variational Autoencoder Graph Convolutional Neural Network framework for generating synthetic Abdominal Aorta Aneurysms (AAA). Using a small real-world dataset, our approach extracts key anatomical features and captures complex statistical relationships within a compact disentangled latent space. To address data limitations, low-impact data augmentation based on Procrustes analysis was employed, preserving anatomical integrity. The generation strategies, both deterministic and stochastic, manage to enhance data diversity while ensuring realism. Compared to PCA-based approaches, our model performs more robustly on unseen data by capturing complex, nonlinear anatomical variations. This enables more comprehensive clinical and statistical analyses than the original dataset alone. The resulting synthetic AAA dataset preserves patient privacy while providing a scalable foundation for medical research, device testing, and computational modeling.
title Graph-Convolutional-Beta-VAE for Synthetic Abdominal Aorta Aneurysm Generation
topic Machine Learning
Artificial Intelligence
Tissues and Organs
url https://arxiv.org/abs/2506.13628