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Main Authors: Mizukami, Masaaki, Tanaka, Yuya
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2506.16752
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author Mizukami, Masaaki
Tanaka, Yuya
author_facet Mizukami, Masaaki
Tanaka, Yuya
contents This paper deals with a problem which describes tuberculosis granuloma formation \begin{align*} \begin{cases} u_t = Δu - \nabla \cdot (u \nabla v) - uv - u + β, &x \in Ω,\ t>0, \\ v_t = Δv + v -uv + μw, &x \in Ω,\ t>0, \\ w_t = Δw + uv - wz - w, &x \in Ω,\ t>0, \\ z_t = Δz - \nabla \cdot (z \nabla w) + f(w)z -z, &x \in Ω,\ t>0 \end{cases} \end{align*} under homogeneous Neumann boundary conditions and initial conditions, where $Ω\subset \mathbb{R}^n$ ($n\ge 2$) is a smooth bounded domain, $β,μ>0$ and $f$ is some function, and shows that if initial data are small in some sense then the solution $(u,v,w,z)$ of the problem exists globally and convergences to $(β,0,0,0)$ exponentially when $β>1$ and the reproduction number $R_0 := \frac{μβ+ 1}β$ satisfies $R_0<1$.
format Preprint
id arxiv_https___arxiv_org_abs_2506_16752
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Boundedness and asymptotic stability in a model for tuberculosis granuloma formation
Mizukami, Masaaki
Tanaka, Yuya
Analysis of PDEs
This paper deals with a problem which describes tuberculosis granuloma formation \begin{align*} \begin{cases} u_t = Δu - \nabla \cdot (u \nabla v) - uv - u + β, &x \in Ω,\ t>0, \\ v_t = Δv + v -uv + μw, &x \in Ω,\ t>0, \\ w_t = Δw + uv - wz - w, &x \in Ω,\ t>0, \\ z_t = Δz - \nabla \cdot (z \nabla w) + f(w)z -z, &x \in Ω,\ t>0 \end{cases} \end{align*} under homogeneous Neumann boundary conditions and initial conditions, where $Ω\subset \mathbb{R}^n$ ($n\ge 2$) is a smooth bounded domain, $β,μ>0$ and $f$ is some function, and shows that if initial data are small in some sense then the solution $(u,v,w,z)$ of the problem exists globally and convergences to $(β,0,0,0)$ exponentially when $β>1$ and the reproduction number $R_0 := \frac{μβ+ 1}β$ satisfies $R_0<1$.
title Boundedness and asymptotic stability in a model for tuberculosis granuloma formation
topic Analysis of PDEs
url https://arxiv.org/abs/2506.16752