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Main Authors: Herceg, Domagoj, DellOro, Marco, Bertollo, Riccardo, Miura, Fuminari, de Klaver, Paul, Breschi, Valentina, Krishnamoorthy, Dinesh, Salazar, Mauro
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2506.17972
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author Herceg, Domagoj
DellOro, Marco
Bertollo, Riccardo
Miura, Fuminari
de Klaver, Paul
Breschi, Valentina
Krishnamoorthy, Dinesh
Salazar, Mauro
author_facet Herceg, Domagoj
DellOro, Marco
Bertollo, Riccardo
Miura, Fuminari
de Klaver, Paul
Breschi, Valentina
Krishnamoorthy, Dinesh
Salazar, Mauro
contents This paper presents a scenario-based model predictive control (MPC) scheme designed to control an evolving pandemic via non-pharmaceutical intervention (NPIs). The proposed approach combines predictions of possible pandemic evolution to decide on a level of severity of NPIs to be implemented over multiple weeks to maintain hospital pressure below a prescribed threshold, while minimizing their impact on society. Specifically, we first introduce a compartmental model which divides the population into Susceptible, Infected, Detected, Threatened, Healed, and Expired (SIDTHE) subpopulations and describe its positive invariant set. This model is expressive enough to explicitly capture the fraction of hospitalized individuals while preserving parameter identifiability w.r.t. publicly available datasets. Second, we devise a scenario-based MPC scheme with recourse actions that captures potential uncertainty of the model parameters. e.g., due to population behavior or seasonality. Our results show that the scenario-based nature of the proposed controller manages to adequately respond to all scenarios, keeping the hospital pressure at bay also in very challenging situations when conventional MPC methods fail.
format Preprint
id arxiv_https___arxiv_org_abs_2506_17972
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle A Scenario-based Model Predictive Control Scheme for Pandemic Response through Non-pharmaceutical Interventions
Herceg, Domagoj
DellOro, Marco
Bertollo, Riccardo
Miura, Fuminari
de Klaver, Paul
Breschi, Valentina
Krishnamoorthy, Dinesh
Salazar, Mauro
Systems and Control
This paper presents a scenario-based model predictive control (MPC) scheme designed to control an evolving pandemic via non-pharmaceutical intervention (NPIs). The proposed approach combines predictions of possible pandemic evolution to decide on a level of severity of NPIs to be implemented over multiple weeks to maintain hospital pressure below a prescribed threshold, while minimizing their impact on society. Specifically, we first introduce a compartmental model which divides the population into Susceptible, Infected, Detected, Threatened, Healed, and Expired (SIDTHE) subpopulations and describe its positive invariant set. This model is expressive enough to explicitly capture the fraction of hospitalized individuals while preserving parameter identifiability w.r.t. publicly available datasets. Second, we devise a scenario-based MPC scheme with recourse actions that captures potential uncertainty of the model parameters. e.g., due to population behavior or seasonality. Our results show that the scenario-based nature of the proposed controller manages to adequately respond to all scenarios, keeping the hospital pressure at bay also in very challenging situations when conventional MPC methods fail.
title A Scenario-based Model Predictive Control Scheme for Pandemic Response through Non-pharmaceutical Interventions
topic Systems and Control
url https://arxiv.org/abs/2506.17972