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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Preprint |
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2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2506.19266 |
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| _version_ | 1866909671366852608 |
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| author | Huang, Jiahao Li, Ruifeng Yu, Wenwen Li, Anan Li, Xiangning Yan, Mingchao Xie, Lei Zeng, Qingrun Jia, Xueyan Wang, Shuxin Ju, Ronghui Chen, Feng Luo, Qingming Gong, Hui Zalesky, Andrew Yang, Xiaoquan Feng, Yuanjing Wang, Zheng |
| author_facet | Huang, Jiahao Li, Ruifeng Yu, Wenwen Li, Anan Li, Xiangning Yan, Mingchao Xie, Lei Zeng, Qingrun Jia, Xueyan Wang, Shuxin Ju, Ronghui Chen, Feng Luo, Qingming Gong, Hui Zalesky, Andrew Yang, Xiaoquan Feng, Yuanjing Wang, Zheng |
| contents | The organization and connectivity of the arcuate fasciculus (AF) in nonhuman primates remain contentious, especially concerning how its anatomy diverges from that of humans. Here, we combined cross-scale single-neuron tracing - using viral-based genetic labeling and fluorescence micro-optical sectioning tomography in macaques (n = 4; age 3 - 11 years) - with whole-brain tractography from 11.7T diffusion MRI. Complemented by spectral embedding analysis of 7.0T MRI in humans, we performed a comparative connectomic analysis of the AF across species. We demonstrate that the macaque AF originates in the temporal-parietal cortex, traverses the auditory cortex and parietal operculum, and projects into prefrontal regions. In contrast, the human AF exhibits greater expansion into the middle temporal gyrus and stronger prefrontal and parietal operculum connectivity - divergences quantified by Kullback-Leibler analysis that likely underpin the evolutionary specialization of human language networks. These interspecies differences - particularly the human AF's broader temporal integration and strengthened frontoparietal linkages - suggest a connectivity-based substrate for the emergence of advanced language processing unique to humans. Furthermore, our findings offer a neuroanatomical framework for understanding AF-related disorders such as aphasia and dyslexia, where aberrant connectivity disrupts language function. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2506_19266 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Convergent and divergent connectivity patterns of the arcuate fasciculus in macaques and humans Huang, Jiahao Li, Ruifeng Yu, Wenwen Li, Anan Li, Xiangning Yan, Mingchao Xie, Lei Zeng, Qingrun Jia, Xueyan Wang, Shuxin Ju, Ronghui Chen, Feng Luo, Qingming Gong, Hui Zalesky, Andrew Yang, Xiaoquan Feng, Yuanjing Wang, Zheng Neurons and Cognition Computer Vision and Pattern Recognition Image and Video Processing The organization and connectivity of the arcuate fasciculus (AF) in nonhuman primates remain contentious, especially concerning how its anatomy diverges from that of humans. Here, we combined cross-scale single-neuron tracing - using viral-based genetic labeling and fluorescence micro-optical sectioning tomography in macaques (n = 4; age 3 - 11 years) - with whole-brain tractography from 11.7T diffusion MRI. Complemented by spectral embedding analysis of 7.0T MRI in humans, we performed a comparative connectomic analysis of the AF across species. We demonstrate that the macaque AF originates in the temporal-parietal cortex, traverses the auditory cortex and parietal operculum, and projects into prefrontal regions. In contrast, the human AF exhibits greater expansion into the middle temporal gyrus and stronger prefrontal and parietal operculum connectivity - divergences quantified by Kullback-Leibler analysis that likely underpin the evolutionary specialization of human language networks. These interspecies differences - particularly the human AF's broader temporal integration and strengthened frontoparietal linkages - suggest a connectivity-based substrate for the emergence of advanced language processing unique to humans. Furthermore, our findings offer a neuroanatomical framework for understanding AF-related disorders such as aphasia and dyslexia, where aberrant connectivity disrupts language function. |
| title | Convergent and divergent connectivity patterns of the arcuate fasciculus in macaques and humans |
| topic | Neurons and Cognition Computer Vision and Pattern Recognition Image and Video Processing |
| url | https://arxiv.org/abs/2506.19266 |