Thermodynamic free energy map for the non-oxidative glycolysis pathways
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arXiv
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| Format: | Preprint |
| Veröffentlicht: |
2025
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| _version_ | 1866916810034511872 |
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| author | Pal, Adittya |
| author_facet | Pal, Adittya |
| contents | Designing reaction pathways that maximize the production of a target compound in a given metabolic network is a fundamental problem in systems biology. In this study, we systematically explore the non-oxidative glycolysis metabolic network, guided by the principle that reactions with negative Gibbs free energy differences are thermodynamically favored. We enumerate alternative pathways that implement the net non-oxidative glycolysis reaction, categorized by their length. Our analysis reveals several alternative thermodynamically favorable pathways beyond those reported in experiments. In addition, we identify molecules within the network, such as 3-hydroxypropionic acid, that may have significant potential for further investigation. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2506_19841 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Thermodynamic free energy map for the non-oxidative glycolysis pathways Pal, Adittya Molecular Networks Systems and Control Biomolecules Designing reaction pathways that maximize the production of a target compound in a given metabolic network is a fundamental problem in systems biology. In this study, we systematically explore the non-oxidative glycolysis metabolic network, guided by the principle that reactions with negative Gibbs free energy differences are thermodynamically favored. We enumerate alternative pathways that implement the net non-oxidative glycolysis reaction, categorized by their length. Our analysis reveals several alternative thermodynamically favorable pathways beyond those reported in experiments. In addition, we identify molecules within the network, such as 3-hydroxypropionic acid, that may have significant potential for further investigation. |
| title | Thermodynamic free energy map for the non-oxidative glycolysis pathways |
| topic | Molecular Networks Systems and Control Biomolecules |
| url | https://arxiv.org/abs/2506.19841 |