CA-Diff: Collaborative Anatomy Diffusion for Brain Tissue Segmentation

Fuente: arXiv
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Main Authors: Xing, Qilong, Song, Zikai, Ye, Yuteng, Chen, Yuke, Zhang, Youjia, Feng, Na, Yu, Junqing, Yang, Wei
Format: Preprint
Published: 2025
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author Xing, Qilong
Song, Zikai
Ye, Yuteng
Chen, Yuke
Zhang, Youjia
Feng, Na
Yu, Junqing
Yang, Wei
author_facet Xing, Qilong
Song, Zikai
Ye, Yuteng
Chen, Yuke
Zhang, Youjia
Feng, Na
Yu, Junqing
Yang, Wei
contents Segmentation of brain structures from MRI is crucial for evaluating brain morphology, yet existing CNN and transformer-based methods struggle to delineate complex structures accurately. While current diffusion models have shown promise in image segmentation, they are inadequate when applied directly to brain MRI due to neglecting anatomical information. To address this, we propose Collaborative Anatomy Diffusion (CA-Diff), a framework integrating spatial anatomical features to enhance segmentation accuracy of the diffusion model. Specifically, we introduce distance field as an auxiliary anatomical condition to provide global spatial context, alongside a collaborative diffusion process to model its joint distribution with anatomical structures, enabling effective utilization of anatomical features for segmentation. Furthermore, we introduce a consistency loss to refine relationships between the distance field and anatomical structures and design a time adapted channel attention module to enhance the U-Net feature fusion procedure. Extensive experiments show that CA-Diff outperforms state-of-the-art (SOTA) methods.
format Preprint
id arxiv_https___arxiv_org_abs_2506_22882
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle CA-Diff: Collaborative Anatomy Diffusion for Brain Tissue Segmentation
Xing, Qilong
Song, Zikai
Ye, Yuteng
Chen, Yuke
Zhang, Youjia
Feng, Na
Yu, Junqing
Yang, Wei
Image and Video Processing
Computer Vision and Pattern Recognition
Machine Learning
Segmentation of brain structures from MRI is crucial for evaluating brain morphology, yet existing CNN and transformer-based methods struggle to delineate complex structures accurately. While current diffusion models have shown promise in image segmentation, they are inadequate when applied directly to brain MRI due to neglecting anatomical information. To address this, we propose Collaborative Anatomy Diffusion (CA-Diff), a framework integrating spatial anatomical features to enhance segmentation accuracy of the diffusion model. Specifically, we introduce distance field as an auxiliary anatomical condition to provide global spatial context, alongside a collaborative diffusion process to model its joint distribution with anatomical structures, enabling effective utilization of anatomical features for segmentation. Furthermore, we introduce a consistency loss to refine relationships between the distance field and anatomical structures and design a time adapted channel attention module to enhance the U-Net feature fusion procedure. Extensive experiments show that CA-Diff outperforms state-of-the-art (SOTA) methods.
title CA-Diff: Collaborative Anatomy Diffusion for Brain Tissue Segmentation
topic Image and Video Processing
Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2506.22882