Emerging AI Approaches for Cancer Spatial Omics

Fuente: arXiv
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Autores principales: Noorbakhsh, Javad, pour, Ali Foroughi, Chuang, Jeffrey
Formato: Preprint
Publicado: 2025
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author Noorbakhsh, Javad
pour, Ali Foroughi
Chuang, Jeffrey
author_facet Noorbakhsh, Javad
pour, Ali Foroughi
Chuang, Jeffrey
contents Technological breakthroughs in spatial omics and artificial intelligence (AI) have the potential to transform the understanding of cancer cells and the tumor microenvironment. Here we review the role of AI in spatial omics, discussing the current state-of-the-art and further needs to decipher cancer biology from large-scale spatial tissue data. An overarching challenge is the development of interpretable spatial AI models, an activity which demands not only improved data integration, but also new conceptual frameworks. We discuss emerging paradigms, in particular data-driven spatial AI, constraint-based spatial AI, and mechanistic spatial modeling, as well as the importance of integrating AI with hypothesis-driven strategies and model systems to realize the value of cancer spatial information.
format Preprint
id arxiv_https___arxiv_org_abs_2506_23857
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Emerging AI Approaches for Cancer Spatial Omics
Noorbakhsh, Javad
pour, Ali Foroughi
Chuang, Jeffrey
Quantitative Methods
Tissues and Organs
Technological breakthroughs in spatial omics and artificial intelligence (AI) have the potential to transform the understanding of cancer cells and the tumor microenvironment. Here we review the role of AI in spatial omics, discussing the current state-of-the-art and further needs to decipher cancer biology from large-scale spatial tissue data. An overarching challenge is the development of interpretable spatial AI models, an activity which demands not only improved data integration, but also new conceptual frameworks. We discuss emerging paradigms, in particular data-driven spatial AI, constraint-based spatial AI, and mechanistic spatial modeling, as well as the importance of integrating AI with hypothesis-driven strategies and model systems to realize the value of cancer spatial information.
title Emerging AI Approaches for Cancer Spatial Omics
topic Quantitative Methods
Tissues and Organs
url https://arxiv.org/abs/2506.23857