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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2507.05236 |
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| _version_ | 1866908613736398848 |
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| author | Palkhivala, Shalom Kohler, Larissa Ritschel, Christian Feldmann, Claus Hunger, David |
| author_facet | Palkhivala, Shalom Kohler, Larissa Ritschel, Christian Feldmann, Claus Hunger, David |
| contents | Nanoparticles are ubiquitous, and methods that reveal insights into single-particle properties are highly desired to enable their advanced characterization. Techniques that achieve label-free single-nanoparticle detection often lack bandwidth or do not provide quantitative information. Here, we present a cavity-based dispersive sensing method that achieves a high bandwidth to capture all relevant timescales of translational diffusion, and a sensitivity to detect and size single particles with diameters down to 3 nm. We develop an analytical model describing the autocorrelation function for particle diffusion in a standing-wave sensing geometry and propose a method to address the challenges posed by the transient nature of single-particle signals. With this, we achieve quantitative particle sizing with high precision and accuracy, and provide an important tool to analyze single-particle diffusion. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2507_05236 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Accurate single-nanoparticle sizing down to 3 nm with an optofluidic microcavity Palkhivala, Shalom Kohler, Larissa Ritschel, Christian Feldmann, Claus Hunger, David Optics Nanoparticles are ubiquitous, and methods that reveal insights into single-particle properties are highly desired to enable their advanced characterization. Techniques that achieve label-free single-nanoparticle detection often lack bandwidth or do not provide quantitative information. Here, we present a cavity-based dispersive sensing method that achieves a high bandwidth to capture all relevant timescales of translational diffusion, and a sensitivity to detect and size single particles with diameters down to 3 nm. We develop an analytical model describing the autocorrelation function for particle diffusion in a standing-wave sensing geometry and propose a method to address the challenges posed by the transient nature of single-particle signals. With this, we achieve quantitative particle sizing with high precision and accuracy, and provide an important tool to analyze single-particle diffusion. |
| title | Accurate single-nanoparticle sizing down to 3 nm with an optofluidic microcavity |
| topic | Optics |
| url | https://arxiv.org/abs/2507.05236 |