Modeling Feasible Locomotion of Nanobots for Cancer Detection and Treatment
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arXiv
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| Main Authors: | , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866915393741783040 |
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| author | Harasha, Noble Gava, Cristina Lynch, Nancy Contini, Claudia Mallmann-Trenn, Frederik |
| author_facet | Harasha, Noble Gava, Cristina Lynch, Nancy Contini, Claudia Mallmann-Trenn, Frederik |
| contents | Deploying motile nanosized particles, also known as ``nanobots'', in the human body promises to improve selectivity in drug delivery and reduce side effects. We consider a swarm of nanobots locating a single cancerous region and treating it by releasing an onboard payload of drugs at the site. At nanoscale, the computation, communication, sensing, and locomotion capabilities of individual agents are extremely limited, noisy, and/or nonexistent.
We present a general model to formally describe the individual and collective behavior of agents in a colloidal environment, such as the bloodstream, for cancer detection and treatment by nanobots. This includes a feasible and precise model of agent locomotion, inspired by actual nanoparticles that, in the presence of an external chemical gradient, move towards areas of higher concentration by means of self-propulsion. We present two variants of our general model: The first assumes an endogenous chemical gradient that is fixed over time and centered at the targeted cancer site; the second is a more speculative and dynamic variant in which agents themselves create and amplify a chemical gradient centered at the cancer site. In both settings, agents can sense the gradient and ascend it noisily, locating the cancer site more quickly than via simple Brownian motion.
For the first variant of the model, we present simulation results to show the behavior of agents under our locomotion model, as well as {analytical results} to bound the time it takes for the agents to reach the cancer site. For the second variant, simulation results highlight the collective benefit in having agents issue their own chemical signal. While arguably more speculative in its agent capability assumptions, this variant shows a significant improvement in runtime performance over the first variant, resulting from its chemical signal amplification mechanism. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2507_12400 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Modeling Feasible Locomotion of Nanobots for Cancer Detection and Treatment Harasha, Noble Gava, Cristina Lynch, Nancy Contini, Claudia Mallmann-Trenn, Frederik Multiagent Systems Discrete Mathematics Deploying motile nanosized particles, also known as ``nanobots'', in the human body promises to improve selectivity in drug delivery and reduce side effects. We consider a swarm of nanobots locating a single cancerous region and treating it by releasing an onboard payload of drugs at the site. At nanoscale, the computation, communication, sensing, and locomotion capabilities of individual agents are extremely limited, noisy, and/or nonexistent. We present a general model to formally describe the individual and collective behavior of agents in a colloidal environment, such as the bloodstream, for cancer detection and treatment by nanobots. This includes a feasible and precise model of agent locomotion, inspired by actual nanoparticles that, in the presence of an external chemical gradient, move towards areas of higher concentration by means of self-propulsion. We present two variants of our general model: The first assumes an endogenous chemical gradient that is fixed over time and centered at the targeted cancer site; the second is a more speculative and dynamic variant in which agents themselves create and amplify a chemical gradient centered at the cancer site. In both settings, agents can sense the gradient and ascend it noisily, locating the cancer site more quickly than via simple Brownian motion. For the first variant of the model, we present simulation results to show the behavior of agents under our locomotion model, as well as {analytical results} to bound the time it takes for the agents to reach the cancer site. For the second variant, simulation results highlight the collective benefit in having agents issue their own chemical signal. While arguably more speculative in its agent capability assumptions, this variant shows a significant improvement in runtime performance over the first variant, resulting from its chemical signal amplification mechanism. |
| title | Modeling Feasible Locomotion of Nanobots for Cancer Detection and Treatment |
| topic | Multiagent Systems Discrete Mathematics |
| url | https://arxiv.org/abs/2507.12400 |