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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2507.14413 |
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| _version_ | 1866911066189987840 |
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| author | Colizzi, Francesco Blázquez-Sánchez, Paula Bussi, Giovanni André, Isabelle Ballabio, Federico Bayer, Thomas Bertocchini, Federica Butenschön, Erik Carosati, Emanuele De Piero, Alessia Di Pede-Mattatelli, Ania Faggian, Leonardo Favaro, Lorenzo Fernandes, Pedro Alexandrino Ferretti, Alfonso Fojan, Peter Gagsteiger, Andreas García-Ruiz, Eva Gardossi, Lucia Giorgino, Toni Graefe, Norbert Gunkel, Jonas Jiménez, Diego J. Keller, Malene Billeskov Künze, Georg Lim, Sierin Lippens, Guy Maria-Solano, Miguel A. Mitusińska, Karolina Moliner, Vicent Molla, Gianluca Myburgh, Marthinus Wessel Panel, Nicolas Ramírez-Sarmiento, César A. Rocher, Dominique Strodel, Birgit Ruiz, Belén Taroncher Turak, Onur Varrone, Cristiano Vezzini, Daniele Westh, Peter Zimmermann, Wolfgang |
| author_facet | Colizzi, Francesco Blázquez-Sánchez, Paula Bussi, Giovanni André, Isabelle Ballabio, Federico Bayer, Thomas Bertocchini, Federica Butenschön, Erik Carosati, Emanuele De Piero, Alessia Di Pede-Mattatelli, Ania Faggian, Leonardo Favaro, Lorenzo Fernandes, Pedro Alexandrino Ferretti, Alfonso Fojan, Peter Gagsteiger, Andreas García-Ruiz, Eva Gardossi, Lucia Giorgino, Toni Graefe, Norbert Gunkel, Jonas Jiménez, Diego J. Keller, Malene Billeskov Künze, Georg Lim, Sierin Lippens, Guy Maria-Solano, Miguel A. Mitusińska, Karolina Moliner, Vicent Molla, Gianluca Myburgh, Marthinus Wessel Panel, Nicolas Ramírez-Sarmiento, César A. Rocher, Dominique Strodel, Birgit Ruiz, Belén Taroncher Turak, Onur Varrone, Cristiano Vezzini, Daniele Westh, Peter Zimmermann, Wolfgang |
| contents | Plastics are essential to modern life, yet poor disposal practices contribute to low recycling rates and environmental accumulation-biological degradation and by-product reuse offer a path to mitigate this global threat. This report highlights key insights, future challenges, and research priorities identified during the CECAM workshop "Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time", held in Trieste from May 6-8, 2025. The workshop brought together an interdisciplinary community of scientists focused on advancing the sustainable use of plastics through enzyme-based degradation. A key point from the discussions is that many bottlenecks in enzymatic recycling arise not only from process engineering challenges, but also from a limited understanding of the underlying molecular mechanisms. We argue that constraints on economic viability and sustainability (e.g., harsh solvents, high temperatures, substrate crystallinity, pretreatments) can-and should-be addressed directly through enzyme design, provided these factors are understood at the molecular level, in synergy with process optimization. For this, it is essential to rely on the integration of experimental and computational approaches to uncover the molecular and mechanistic basis of enzymatic plastic degradation. We highlight how the small-format structure of the workshop, in line with the usual CECAM format, fostered a collaborative, friendly, and relaxed atmosphere. We hope this report encourages future initiatives and the formation of shared consortia to support an open, collaborative, and bio-based plastic recycling community. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2507_14413 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time Colizzi, Francesco Blázquez-Sánchez, Paula Bussi, Giovanni André, Isabelle Ballabio, Federico Bayer, Thomas Bertocchini, Federica Butenschön, Erik Carosati, Emanuele De Piero, Alessia Di Pede-Mattatelli, Ania Faggian, Leonardo Favaro, Lorenzo Fernandes, Pedro Alexandrino Ferretti, Alfonso Fojan, Peter Gagsteiger, Andreas García-Ruiz, Eva Gardossi, Lucia Giorgino, Toni Graefe, Norbert Gunkel, Jonas Jiménez, Diego J. Keller, Malene Billeskov Künze, Georg Lim, Sierin Lippens, Guy Maria-Solano, Miguel A. Mitusińska, Karolina Moliner, Vicent Molla, Gianluca Myburgh, Marthinus Wessel Panel, Nicolas Ramírez-Sarmiento, César A. Rocher, Dominique Strodel, Birgit Ruiz, Belén Taroncher Turak, Onur Varrone, Cristiano Vezzini, Daniele Westh, Peter Zimmermann, Wolfgang Biomolecules Plastics are essential to modern life, yet poor disposal practices contribute to low recycling rates and environmental accumulation-biological degradation and by-product reuse offer a path to mitigate this global threat. This report highlights key insights, future challenges, and research priorities identified during the CECAM workshop "Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time", held in Trieste from May 6-8, 2025. The workshop brought together an interdisciplinary community of scientists focused on advancing the sustainable use of plastics through enzyme-based degradation. A key point from the discussions is that many bottlenecks in enzymatic recycling arise not only from process engineering challenges, but also from a limited understanding of the underlying molecular mechanisms. We argue that constraints on economic viability and sustainability (e.g., harsh solvents, high temperatures, substrate crystallinity, pretreatments) can-and should-be addressed directly through enzyme design, provided these factors are understood at the molecular level, in synergy with process optimization. For this, it is essential to rely on the integration of experimental and computational approaches to uncover the molecular and mechanistic basis of enzymatic plastic degradation. We highlight how the small-format structure of the workshop, in line with the usual CECAM format, fostered a collaborative, friendly, and relaxed atmosphere. We hope this report encourages future initiatives and the formation of shared consortia to support an open, collaborative, and bio-based plastic recycling community. |
| title | Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time |
| topic | Biomolecules |
| url | https://arxiv.org/abs/2507.14413 |