UniSegDiff: Boosting Unified Lesion Segmentation via a Staged Diffusion Model

Fuente: arXiv
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Main Authors: Hu, Yilong, Chang, Shijie, Zhang, Lihe, Tian, Feng, Sun, Weibing, Lu, Huchuan
Format: Preprint
Published: 2025
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author Hu, Yilong
Chang, Shijie
Zhang, Lihe
Tian, Feng
Sun, Weibing
Lu, Huchuan
author_facet Hu, Yilong
Chang, Shijie
Zhang, Lihe
Tian, Feng
Sun, Weibing
Lu, Huchuan
contents The Diffusion Probabilistic Model (DPM) has demonstrated remarkable performance across a variety of generative tasks. The inherent randomness in diffusion models helps address issues such as blurring at the edges of medical images and labels, positioning Diffusion Probabilistic Models (DPMs) as a promising approach for lesion segmentation. However, we find that the current training and inference strategies of diffusion models result in an uneven distribution of attention across different timesteps, leading to longer training times and suboptimal solutions. To this end, we propose UniSegDiff, a novel diffusion model framework designed to address lesion segmentation in a unified manner across multiple modalities and organs. This framework introduces a staged training and inference approach, dynamically adjusting the prediction targets at different stages, forcing the model to maintain high attention across all timesteps, and achieves unified lesion segmentation through pre-training the feature extraction network for segmentation. We evaluate performance on six different organs across various imaging modalities. Comprehensive experimental results demonstrate that UniSegDiff significantly outperforms previous state-of-the-art (SOTA) approaches. The code is available at https://github.com/HUYILONG-Z/UniSegDiff.
format Preprint
id arxiv_https___arxiv_org_abs_2507_18362
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle UniSegDiff: Boosting Unified Lesion Segmentation via a Staged Diffusion Model
Hu, Yilong
Chang, Shijie
Zhang, Lihe
Tian, Feng
Sun, Weibing
Lu, Huchuan
Image and Video Processing
Computer Vision and Pattern Recognition
The Diffusion Probabilistic Model (DPM) has demonstrated remarkable performance across a variety of generative tasks. The inherent randomness in diffusion models helps address issues such as blurring at the edges of medical images and labels, positioning Diffusion Probabilistic Models (DPMs) as a promising approach for lesion segmentation. However, we find that the current training and inference strategies of diffusion models result in an uneven distribution of attention across different timesteps, leading to longer training times and suboptimal solutions. To this end, we propose UniSegDiff, a novel diffusion model framework designed to address lesion segmentation in a unified manner across multiple modalities and organs. This framework introduces a staged training and inference approach, dynamically adjusting the prediction targets at different stages, forcing the model to maintain high attention across all timesteps, and achieves unified lesion segmentation through pre-training the feature extraction network for segmentation. We evaluate performance on six different organs across various imaging modalities. Comprehensive experimental results demonstrate that UniSegDiff significantly outperforms previous state-of-the-art (SOTA) approaches. The code is available at https://github.com/HUYILONG-Z/UniSegDiff.
title UniSegDiff: Boosting Unified Lesion Segmentation via a Staged Diffusion Model
topic Image and Video Processing
Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2507.18362