Open problems in ageing science: A roadmap for biogerontology
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arXiv
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| _version_ | 1866912499932069888 |
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| author | Talay, Angelo Belikov, Aleksey V. To, Paul Ka Po Alfatemi, Hamid H. Alon, Uri Deelen, Joris Ewald, Collin Y. Gems, David Gorbunova, Vera Gruber, Jan Hägg, Sara Hemming, John Horvath, Steve Kaya, Alaattin Lewis, Caitlin J. Maier, Andrea Marinova, Maria B Pawelec, Graham Peleg, Shahaf Rattan, Suresh Scheibye-Knudsen, Morten Schmauck-Medina, Tomas Saroyan, Vardan Seluanov, Andrei Stolzing, Alexandra Teeling, Emma Williams, Robert W. White, Todd Unfried, Maximilian de Magalhães, João Pedro |
| author_facet | Talay, Angelo Belikov, Aleksey V. To, Paul Ka Po Alfatemi, Hamid H. Alon, Uri Deelen, Joris Ewald, Collin Y. Gems, David Gorbunova, Vera Gruber, Jan Hägg, Sara Hemming, John Horvath, Steve Kaya, Alaattin Lewis, Caitlin J. Maier, Andrea Marinova, Maria B Pawelec, Graham Peleg, Shahaf Rattan, Suresh Scheibye-Knudsen, Morten Schmauck-Medina, Tomas Saroyan, Vardan Seluanov, Andrei Stolzing, Alexandra Teeling, Emma Williams, Robert W. White, Todd Unfried, Maximilian de Magalhães, João Pedro |
| contents | The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorized into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers, and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website (www.longevityknowledge.app). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2507_18602 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Open problems in ageing science: A roadmap for biogerontology Talay, Angelo Belikov, Aleksey V. To, Paul Ka Po Alfatemi, Hamid H. Alon, Uri Deelen, Joris Ewald, Collin Y. Gems, David Gorbunova, Vera Gruber, Jan Hägg, Sara Hemming, John Horvath, Steve Kaya, Alaattin Lewis, Caitlin J. Maier, Andrea Marinova, Maria B Pawelec, Graham Peleg, Shahaf Rattan, Suresh Scheibye-Knudsen, Morten Schmauck-Medina, Tomas Saroyan, Vardan Seluanov, Andrei Stolzing, Alexandra Teeling, Emma Williams, Robert W. White, Todd Unfried, Maximilian de Magalhães, João Pedro Other Quantitative Biology The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorized into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers, and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website (www.longevityknowledge.app). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology. |
| title | Open problems in ageing science: A roadmap for biogerontology |
| topic | Other Quantitative Biology |
| url | https://arxiv.org/abs/2507.18602 |