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Main Authors: Sousa, Lisa Barros de Andrade e, Miller, Gregor, Gleut, Ronan Le, Thalmeier, Dominik, Pelin, Helena, Piraud, Marie
Format: Preprint
Published: 2025
Subjects:
Online Access:https://arxiv.org/abs/2507.19455
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author Sousa, Lisa Barros de Andrade e
Miller, Gregor
Gleut, Ronan Le
Thalmeier, Dominik
Pelin, Helena
Piraud, Marie
author_facet Sousa, Lisa Barros de Andrade e
Miller, Gregor
Gleut, Ronan Le
Thalmeier, Dominik
Pelin, Helena
Piraud, Marie
contents As machine learning models are increasingly deployed in sensitive application areas, the demand for interpretable and trustworthy decision-making has increased. Random Forests (RF), despite their widespread use and strong performance on tabular data, remain difficult to interpret due to their ensemble nature. We present Forest-Guided Clustering (FGC), a model-specific explainability method that reveals both local and global structure in RFs by grouping instances according to shared decision paths. FGC produces human-interpretable clusters aligned with the model's internal logic and computes cluster-specific and global feature importance scores to derive decision rules underlying RF predictions. FGC accurately recovered latent subclass structure on a benchmark dataset and outperformed classical clustering and post-hoc explanation methods. Applied to an AML transcriptomic dataset, FGC uncovered biologically coherent subpopulations, disentangled disease-relevant signals from confounders, and recovered known and novel gene expression patterns. FGC bridges the gap between performance and interpretability by providing structure-aware insights that go beyond feature-level attribution.
format Preprint
id arxiv_https___arxiv_org_abs_2507_19455
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Forest-Guided Clustering -- Shedding Light into the Random Forest Black Box
Sousa, Lisa Barros de Andrade e
Miller, Gregor
Gleut, Ronan Le
Thalmeier, Dominik
Pelin, Helena
Piraud, Marie
Machine Learning
As machine learning models are increasingly deployed in sensitive application areas, the demand for interpretable and trustworthy decision-making has increased. Random Forests (RF), despite their widespread use and strong performance on tabular data, remain difficult to interpret due to their ensemble nature. We present Forest-Guided Clustering (FGC), a model-specific explainability method that reveals both local and global structure in RFs by grouping instances according to shared decision paths. FGC produces human-interpretable clusters aligned with the model's internal logic and computes cluster-specific and global feature importance scores to derive decision rules underlying RF predictions. FGC accurately recovered latent subclass structure on a benchmark dataset and outperformed classical clustering and post-hoc explanation methods. Applied to an AML transcriptomic dataset, FGC uncovered biologically coherent subpopulations, disentangled disease-relevant signals from confounders, and recovered known and novel gene expression patterns. FGC bridges the gap between performance and interpretability by providing structure-aware insights that go beyond feature-level attribution.
title Forest-Guided Clustering -- Shedding Light into the Random Forest Black Box
topic Machine Learning
url https://arxiv.org/abs/2507.19455