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| Main Authors: | , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2508.02767 |
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| _version_ | 1866916880660299776 |
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| author | Baraldi, Laura De Angelis, Davide Bosi, Roberto Pennini, Roberto Bassanetti, Irene Benassi, Andrea Bellazzi, Guido Enrico |
| author_facet | Baraldi, Laura De Angelis, Davide Bosi, Roberto Pennini, Roberto Bassanetti, Irene Benassi, Andrea Bellazzi, Guido Enrico |
| contents | Controlling the size of powder particles is pivotal in the design of many pharmaceutical forms and the related manufacturing processes and plants. One of the most common techniques for particle size reduction in process industry is powder milling, whose efficiency relates to the mechanical properties of powder particles themselves. In this work, we first characterize the elastic and plastic response of different pharmaceutical powders by measuring their Young modulus, the hardness and the brittleness index via nano-indentation. Subsequently, we analyze the behavior of those powder samples during comminution via jet-mill at different process conditions. Finally, the correlation between single particle mechanical properties and milling process results is illustrated; the possibility to build a predictive model for powder grindability, based on nano-indentation data, is critically discussed |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2508_02767 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Mechanical characterization of pharmaceutical powders and correlation with their behavior during grinding Baraldi, Laura De Angelis, Davide Bosi, Roberto Pennini, Roberto Bassanetti, Irene Benassi, Andrea Bellazzi, Guido Enrico Medical Physics Materials Science Controlling the size of powder particles is pivotal in the design of many pharmaceutical forms and the related manufacturing processes and plants. One of the most common techniques for particle size reduction in process industry is powder milling, whose efficiency relates to the mechanical properties of powder particles themselves. In this work, we first characterize the elastic and plastic response of different pharmaceutical powders by measuring their Young modulus, the hardness and the brittleness index via nano-indentation. Subsequently, we analyze the behavior of those powder samples during comminution via jet-mill at different process conditions. Finally, the correlation between single particle mechanical properties and milling process results is illustrated; the possibility to build a predictive model for powder grindability, based on nano-indentation data, is critically discussed |
| title | Mechanical characterization of pharmaceutical powders and correlation with their behavior during grinding |
| topic | Medical Physics Materials Science |
| url | https://arxiv.org/abs/2508.02767 |