When is String Reconstruction using de Bruijn Graphs Hard?
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arXiv
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| Auteurs principaux: | , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866909849147670528 |
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| author | Bals, Ben van Krieken, Sebastiaan Pissis, Solon P. Stougie, Leen Verbeek, Hilde |
| author_facet | Bals, Ben van Krieken, Sebastiaan Pissis, Solon P. Stougie, Leen Verbeek, Hilde |
| contents | The reduction of the fragment assembly problem to (variations of) the classical Eulerian trail problem [Pevzner et al., PNAS 2001] has led to remarkable progress in genome assembly. This reduction employs the notion of de Bruijn graph $G=(V,E)$ of order $k$ over an alphabet $Σ$. A single Eulerian trail in $G$ represents a candidate genome reconstruction. Bernardini et al. have also introduced the complementary idea in data privacy [ALENEX 2020] based on $z$-anonymity.
The pressing question is: How hard is it to reconstruct a best string from a de Bruijn graph given a function that models domain knowledge? Such a function maps every length-$k$ string to an interval of positions where it may occur in the reconstructed string. By the above reduction to de Bruijn graphs, the latter function translates into a function $c$ mapping every edge to an interval where it may occur in an Eulerian trail. This gives rise to the following basic problem on graphs: Given an instance $(G,c)$, can we efficiently compute an Eulerian trail respecting $c$? Hannenhalli et al.~[CABIOS 1996] formalized this problem and showed that it is NP-complete.
We focus on parametrization aiming to capture the quality of our domain knowledge in the complexity. Ben-Dor et al. developed an algorithm to solve the problem on de Bruijn graphs in $O(m \cdot w^{1.5} 4^{w})$ time, where $m=|E|$ and $w$ is the maximum interval length over all edges. Bumpus and Meeks [Algorithmica 2023] rediscovered the same algorithm on temporal graphs, highlighting the relevance of this problem in other contexts. We give combinatorial insights that lead to exponential-time improvements over the state-of-the-art. For the important class of de Bruijn graphs, we develop an algorithm parametrized by $w (\log w+1) /(k-1)$. Our improved algorithm shows that it is enough when the range of positions is small relative to $k$. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2508_03433 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | When is String Reconstruction using de Bruijn Graphs Hard? Bals, Ben van Krieken, Sebastiaan Pissis, Solon P. Stougie, Leen Verbeek, Hilde Data Structures and Algorithms The reduction of the fragment assembly problem to (variations of) the classical Eulerian trail problem [Pevzner et al., PNAS 2001] has led to remarkable progress in genome assembly. This reduction employs the notion of de Bruijn graph $G=(V,E)$ of order $k$ over an alphabet $Σ$. A single Eulerian trail in $G$ represents a candidate genome reconstruction. Bernardini et al. have also introduced the complementary idea in data privacy [ALENEX 2020] based on $z$-anonymity. The pressing question is: How hard is it to reconstruct a best string from a de Bruijn graph given a function that models domain knowledge? Such a function maps every length-$k$ string to an interval of positions where it may occur in the reconstructed string. By the above reduction to de Bruijn graphs, the latter function translates into a function $c$ mapping every edge to an interval where it may occur in an Eulerian trail. This gives rise to the following basic problem on graphs: Given an instance $(G,c)$, can we efficiently compute an Eulerian trail respecting $c$? Hannenhalli et al.~[CABIOS 1996] formalized this problem and showed that it is NP-complete. We focus on parametrization aiming to capture the quality of our domain knowledge in the complexity. Ben-Dor et al. developed an algorithm to solve the problem on de Bruijn graphs in $O(m \cdot w^{1.5} 4^{w})$ time, where $m=|E|$ and $w$ is the maximum interval length over all edges. Bumpus and Meeks [Algorithmica 2023] rediscovered the same algorithm on temporal graphs, highlighting the relevance of this problem in other contexts. We give combinatorial insights that lead to exponential-time improvements over the state-of-the-art. For the important class of de Bruijn graphs, we develop an algorithm parametrized by $w (\log w+1) /(k-1)$. Our improved algorithm shows that it is enough when the range of positions is small relative to $k$. |
| title | When is String Reconstruction using de Bruijn Graphs Hard? |
| topic | Data Structures and Algorithms |
| url | https://arxiv.org/abs/2508.03433 |