Delay-constrained re-entry governs large-scale brain seizures and other network pathologies
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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866915433166143488 |
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| author | Triebkorn, Paul Wang, Huifang E. Woodman, Marmaduke Guye, Maxime Bartolomei, Fabrice Jirsa, Viktor |
| author_facet | Triebkorn, Paul Wang, Huifang E. Woodman, Marmaduke Guye, Maxime Bartolomei, Fabrice Jirsa, Viktor |
| contents | Re-entry of travelling excitation loops is a long-suspected driver of human seizures, yet how such loops arise in patient brain networks -- and how susceptible they are to targeted disruption -- remains unclear. We reconstruct a millimetre-scale virtual brain from diffusion MRI of a drug-resistant epilepsy patient, embed excitable Epileptor neural fields, and show that realistic cortico-cortical delays are sufficient to generate self-sustaining re-entry. Systematic parameter sweeps reveal a narrow delay-coupling window that predicts oscillation frequency and seizure duration across 184 recorded seizures. Precisely timed biphasic stimuli or sub-millimetre virtual lesions abort re-entry in silico, yielding phase-dependent termination rules validated in intracranial recordings. Our framework exposes delay-constrained re-entry as a generic dynamical mechanism for large-scale brain synchrony and provides a patient-specific testbed for precision neuromodulation and minimally invasive disconnection. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2508_04824 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Delay-constrained re-entry governs large-scale brain seizures and other network pathologies Triebkorn, Paul Wang, Huifang E. Woodman, Marmaduke Guye, Maxime Bartolomei, Fabrice Jirsa, Viktor Neurons and Cognition Re-entry of travelling excitation loops is a long-suspected driver of human seizures, yet how such loops arise in patient brain networks -- and how susceptible they are to targeted disruption -- remains unclear. We reconstruct a millimetre-scale virtual brain from diffusion MRI of a drug-resistant epilepsy patient, embed excitable Epileptor neural fields, and show that realistic cortico-cortical delays are sufficient to generate self-sustaining re-entry. Systematic parameter sweeps reveal a narrow delay-coupling window that predicts oscillation frequency and seizure duration across 184 recorded seizures. Precisely timed biphasic stimuli or sub-millimetre virtual lesions abort re-entry in silico, yielding phase-dependent termination rules validated in intracranial recordings. Our framework exposes delay-constrained re-entry as a generic dynamical mechanism for large-scale brain synchrony and provides a patient-specific testbed for precision neuromodulation and minimally invasive disconnection. |
| title | Delay-constrained re-entry governs large-scale brain seizures and other network pathologies |
| topic | Neurons and Cognition |
| url | https://arxiv.org/abs/2508.04824 |