Detecting Early Kidney Allograft Fibrosis with Multi-b-value Spectral Diffusion MRI
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arXiv
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| Natura: | Preprint |
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2025
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| author | Liu, Mira M. Dyke, Jonathan Gladytz, Thomas Jasse, Jonas Bolger, Ian Calle, Sergio Pavuluri, Swathi Crews, Tanner Seshan, Surya Salvatore, Steven Stillman, Isaac Muthukumar, Thangamani Taouli, Bachir Farouk, Samira Bane, Octavia Lewis, Sara |
| author_facet | Liu, Mira M. Dyke, Jonathan Gladytz, Thomas Jasse, Jonas Bolger, Ian Calle, Sergio Pavuluri, Swathi Crews, Tanner Seshan, Surya Salvatore, Steven Stillman, Isaac Muthukumar, Thangamani Taouli, Bachir Farouk, Samira Bane, Octavia Lewis, Sara |
| contents | Kidney allograft fibrosis is a marker of chronic kidney disease (CKD) and predicts functional decline, and eventual allograft failure. This study evaluates if spectral diffusion MRI can help detect early development and mild/moderate fibrosis in kidney allografts. In a prospective two-center study of kidney allografts, interstitial fibrosis and tubular atrophy (IFTA) was scored and eGFR was calculated from serum creatinine. Multi-b-value DWI (bvalues=[0,10,30,50,80,120,200,400,800mm2/s]) was post-processed with spectral diffusion, intravoxel incoherent motion (IVIM), and apparent diffusion coefficient (ADC). Connection between imaging parameters and biological processes was measured by Mann-Whitney U-test and Spearman's rank; diagnostic ability was measured by five-fold cross-validation univariate and multi-variate logistic regression. Quality control analyses included volunteer MRI (n=4) and inter-observer analysis (n=19). 99 patients were included (50$\pm$13yo, 64M/35F, 39 IFTA=0, 22 IFTA=2, 20 IFTA=4, 18 IFTA=6, 46 eGFR<=45mL/min/1.73m2, mean eGFR=47.5$\pm$21.3mL/min/1.73m2). Spectral diffusion detected fibrosis (IFTA>0) in patients with normal/stable eGFR>45ml/min/1.73m2 [AUC(95$\%$CI)=0.72(0.56,0.87),p=0.007]. Spectral diffusion detected mild/moderate fibrosis (IFTA=2-4) [AUC(95$\%$CI)=0.65(0.52,0.71),p=0.023], as did ADC [AUC(95$\%$CI)=0.71(0.54,0.87),p=0.013)]. eGFR, time-from-transplant, and allograft size could not. Interobserver correlation was >0.50 in 24 out of 40 diffusion parameters. Spectral diffusion MRI showed detection of mild/moderate fibrosis and fibrosis before decline in function. It is a promising method to detect early development of fibrosis and CKD before progression. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2508_06644 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Detecting Early Kidney Allograft Fibrosis with Multi-b-value Spectral Diffusion MRI Liu, Mira M. Dyke, Jonathan Gladytz, Thomas Jasse, Jonas Bolger, Ian Calle, Sergio Pavuluri, Swathi Crews, Tanner Seshan, Surya Salvatore, Steven Stillman, Isaac Muthukumar, Thangamani Taouli, Bachir Farouk, Samira Bane, Octavia Lewis, Sara Medical Physics Image and Video Processing Kidney allograft fibrosis is a marker of chronic kidney disease (CKD) and predicts functional decline, and eventual allograft failure. This study evaluates if spectral diffusion MRI can help detect early development and mild/moderate fibrosis in kidney allografts. In a prospective two-center study of kidney allografts, interstitial fibrosis and tubular atrophy (IFTA) was scored and eGFR was calculated from serum creatinine. Multi-b-value DWI (bvalues=[0,10,30,50,80,120,200,400,800mm2/s]) was post-processed with spectral diffusion, intravoxel incoherent motion (IVIM), and apparent diffusion coefficient (ADC). Connection between imaging parameters and biological processes was measured by Mann-Whitney U-test and Spearman's rank; diagnostic ability was measured by five-fold cross-validation univariate and multi-variate logistic regression. Quality control analyses included volunteer MRI (n=4) and inter-observer analysis (n=19). 99 patients were included (50$\pm$13yo, 64M/35F, 39 IFTA=0, 22 IFTA=2, 20 IFTA=4, 18 IFTA=6, 46 eGFR<=45mL/min/1.73m2, mean eGFR=47.5$\pm$21.3mL/min/1.73m2). Spectral diffusion detected fibrosis (IFTA>0) in patients with normal/stable eGFR>45ml/min/1.73m2 [AUC(95$\%$CI)=0.72(0.56,0.87),p=0.007]. Spectral diffusion detected mild/moderate fibrosis (IFTA=2-4) [AUC(95$\%$CI)=0.65(0.52,0.71),p=0.023], as did ADC [AUC(95$\%$CI)=0.71(0.54,0.87),p=0.013)]. eGFR, time-from-transplant, and allograft size could not. Interobserver correlation was >0.50 in 24 out of 40 diffusion parameters. Spectral diffusion MRI showed detection of mild/moderate fibrosis and fibrosis before decline in function. It is a promising method to detect early development of fibrosis and CKD before progression. |
| title | Detecting Early Kidney Allograft Fibrosis with Multi-b-value Spectral Diffusion MRI |
| topic | Medical Physics Image and Video Processing |
| url | https://arxiv.org/abs/2508.06644 |