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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2508.07899 |
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Table of Contents:
- Mass density is a vital property for improved biophysical understanding of and within biological samples. It is increasingly attracting active investigation, but still lacks reliable, non-contact techniques to accurately characterize it in biological systems. Contrary to popular belief, refractive index information alone is insufficient to determine a sample's mass density, as we demonstrate here theoretically and experimentally. Instead, we measured the nonlinear gain of stimulated Brillouin scattering to provide additional information for mass density estimation. This all-optical method reduces the estimation error tenfold, offering a more accurate and universal technique for mass density measurements.