An Interactive Platform for Unified Assessment of Drug-Drug Interactions Using Descriptive and Pharmacokinetic Data
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arXiv
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866908484960780288 |
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| author | Diadkina, Nadezhda |
| author_facet | Diadkina, Nadezhda |
| contents | Drug-drug interactions (DDIs) are a major concern in polypharmacy. Public databases often provide only qualitative descriptions without pharmacokinetic context. We present an interactive web tool that integrates 191,541 descriptive DDI records from DrugBank with 3,779 AUC-based interactions from the PK-DDIP dataset, extracted from FDA-approved drug labeling (DailyMed) using natural language processing and manual verification. Using multi-step name harmonization (exact, fuzzy, synonym expansion, manual curation), 1,803 interaction pairs were unified across 639 overlapping compounds. The platform is built with Streamlit and offers smart drug search, color-coded output, and real-time response. It enables users to explore both descriptive and pharmacokinetic data, supporting research and education in clinical pharmacology and drug safety. This research prototype is not intended for clinical decision-making. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2508_08351 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | An Interactive Platform for Unified Assessment of Drug-Drug Interactions Using Descriptive and Pharmacokinetic Data Diadkina, Nadezhda Quantitative Methods Drug-drug interactions (DDIs) are a major concern in polypharmacy. Public databases often provide only qualitative descriptions without pharmacokinetic context. We present an interactive web tool that integrates 191,541 descriptive DDI records from DrugBank with 3,779 AUC-based interactions from the PK-DDIP dataset, extracted from FDA-approved drug labeling (DailyMed) using natural language processing and manual verification. Using multi-step name harmonization (exact, fuzzy, synonym expansion, manual curation), 1,803 interaction pairs were unified across 639 overlapping compounds. The platform is built with Streamlit and offers smart drug search, color-coded output, and real-time response. It enables users to explore both descriptive and pharmacokinetic data, supporting research and education in clinical pharmacology and drug safety. This research prototype is not intended for clinical decision-making. |
| title | An Interactive Platform for Unified Assessment of Drug-Drug Interactions Using Descriptive and Pharmacokinetic Data |
| topic | Quantitative Methods |
| url | https://arxiv.org/abs/2508.08351 |