Nonparametric Bayesian Multi-Treatment Mixture Cure Survival Model with Application in Pediatric Oncology
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| Main Authors: | , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866912673316208640 |
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| author | Chang, Peter Kairalla, John Roy, Arkaprava |
| author_facet | Chang, Peter Kairalla, John Roy, Arkaprava |
| contents | Heterogeneous treatment effect estimation is critical in oncology, particularly in multi-arm trials with overlapping therapeutic components and long-term survivors. These shared mechanisms pose a central challenge to identifying causal effects in precision medicine. We propose a novel covariate-dependent nonparametric Bayesian multi-treatment cure survival model that jointly accounts for common structures among treatments and cure fractions. Through latent link functions, our model leverages sharing among treatments through a flexible modeling approach, enabling individualized survival inference. We adopt a Bayesian route for inference and implement an efficient MCMC algorithm for approximating the posterior. Simulation studies demonstrate the method's robustness and superiority in various specification scenarios. Finally, application to the AALL0434 trial reveals clinically meaningful differences in survival across methotrexate-based regimens and their associations with different covariates, underscoring its practical utility for learning treatment effects in real-world pediatric oncology data. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2508_08975 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Nonparametric Bayesian Multi-Treatment Mixture Cure Survival Model with Application in Pediatric Oncology Chang, Peter Kairalla, John Roy, Arkaprava Methodology Applications Heterogeneous treatment effect estimation is critical in oncology, particularly in multi-arm trials with overlapping therapeutic components and long-term survivors. These shared mechanisms pose a central challenge to identifying causal effects in precision medicine. We propose a novel covariate-dependent nonparametric Bayesian multi-treatment cure survival model that jointly accounts for common structures among treatments and cure fractions. Through latent link functions, our model leverages sharing among treatments through a flexible modeling approach, enabling individualized survival inference. We adopt a Bayesian route for inference and implement an efficient MCMC algorithm for approximating the posterior. Simulation studies demonstrate the method's robustness and superiority in various specification scenarios. Finally, application to the AALL0434 trial reveals clinically meaningful differences in survival across methotrexate-based regimens and their associations with different covariates, underscoring its practical utility for learning treatment effects in real-world pediatric oncology data. |
| title | Nonparametric Bayesian Multi-Treatment Mixture Cure Survival Model with Application in Pediatric Oncology |
| topic | Methodology Applications |
| url | https://arxiv.org/abs/2508.08975 |