A Novel Nonlinear IP$_3$R State Transition Model and Calcium Oscillation
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arXiv
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| Auteurs principaux: | , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866909740391464960 |
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| author | Peng, Zhao-Yu Jiang, Han-Yu He, Jun |
| author_facet | Peng, Zhao-Yu Jiang, Han-Yu He, Jun |
| contents | We present a novel nonlinear state transition model for inositol 1,4,5-trisphosphate receptors (IP$_3$Rs) that incorporates a pre-activated state, as suggested by electron microscopy observations. Our model provides a theoretical framework for the biphasic Ca$^{2+}$ dependence of IP$_3$Rs and accurately reproduces their experimentally observed state distribution under saturating IP$_3$ conditions. By integrating receptor dynamics with cytoplasmic and endoplasmic reticulum (ER) calcium exchange, we simulate IP$_3$R-mediated Ca$^{2+}$ oscillations governed by six key conformational states. A pivotal finding is that IP$_3$ regulates these oscillations in a switch-like manner: once a critical IP$_3$ concentration is reached, the system abruptly transitions to sustained, constant-amplitude oscillations that quickly terminate when the concentration exceeds a secondary threshold. These results underscore the crucial role of the pre-activated state in modulating calcium signaling. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2508_12693 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | A Novel Nonlinear IP$_3$R State Transition Model and Calcium Oscillation Peng, Zhao-Yu Jiang, Han-Yu He, Jun Biological Physics Subcellular Processes We present a novel nonlinear state transition model for inositol 1,4,5-trisphosphate receptors (IP$_3$Rs) that incorporates a pre-activated state, as suggested by electron microscopy observations. Our model provides a theoretical framework for the biphasic Ca$^{2+}$ dependence of IP$_3$Rs and accurately reproduces their experimentally observed state distribution under saturating IP$_3$ conditions. By integrating receptor dynamics with cytoplasmic and endoplasmic reticulum (ER) calcium exchange, we simulate IP$_3$R-mediated Ca$^{2+}$ oscillations governed by six key conformational states. A pivotal finding is that IP$_3$ regulates these oscillations in a switch-like manner: once a critical IP$_3$ concentration is reached, the system abruptly transitions to sustained, constant-amplitude oscillations that quickly terminate when the concentration exceeds a secondary threshold. These results underscore the crucial role of the pre-activated state in modulating calcium signaling. |
| title | A Novel Nonlinear IP$_3$R State Transition Model and Calcium Oscillation |
| topic | Biological Physics Subcellular Processes |
| url | https://arxiv.org/abs/2508.12693 |