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| Autores principales: | , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| Materias: | |
| Acceso en línea: | https://arxiv.org/abs/2508.15762 |
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| _version_ | 1866908497464000512 |
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| author | Baidoo, D. Kubuafor, E. Osarfo, S. F. Agyei-Owusu, F. A. Frimpong, J. A. Amevor, R. Duah, A. Aboagye, F. |
| author_facet | Baidoo, D. Kubuafor, E. Osarfo, S. F. Agyei-Owusu, F. A. Frimpong, J. A. Amevor, R. Duah, A. Aboagye, F. |
| contents | Cervical dystonia, a debilitating neurological disorder marked by involuntary muscle contractions and chronic pain, presents significant treatment challenges despite advances in botulinum toxin therapy. While botulinum toxin type B has emerged as one of the leading treatments, comparative efficacy across doses and the influence of demographic factors for personalized medicine remain understudied. This study aimed to: (1) compare the efficacy of different botulinum toxin type B doses using Bayesian methods, (2) evaluate demographic and clinical factors affecting treatment response, and (3) establish a probabilistic framework for personalized cervical dystonia management. We analyzed data from a multicenter randomized controlled trial involving 109 patients assigned to placebo, 5,000 units, or 10,000 units of botulinum toxin type B groups. The primary outcome was the Toronto Western Spasmodic Torticollis Rating Scale measured over 16 weeks. Bayesian hierarchical modeling assessed treatment effects while accounting for patient heterogeneity. Lower botulinum toxin type B doses (5,000 units) showed greater overall Toronto Western Spasmodic Torticollis Rating Scale score reductions (treatment effect: -2.39, 95% Probability Interval: -4.10 to -0.70). Male patients demonstrated better responses (5.2% greater improvement) than female patients. Substantial between-patient variability and site-specific effects were observed, highlighting the need for personalized protocols. The study confirms botulinum toxin type B's dose-dependent efficacy while identifying key modifiable factors in treatment response. Bayesian methods provided nuanced insights into uncertainty and heterogeneity, paving the way for personalized medicine in cervical dystonia management. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2508_15762 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Bayesian Hierarchical Methods for Surveillance of Cervical Dystonia Treatments Baidoo, D. Kubuafor, E. Osarfo, S. F. Agyei-Owusu, F. A. Frimpong, J. A. Amevor, R. Duah, A. Aboagye, F. Applications Cervical dystonia, a debilitating neurological disorder marked by involuntary muscle contractions and chronic pain, presents significant treatment challenges despite advances in botulinum toxin therapy. While botulinum toxin type B has emerged as one of the leading treatments, comparative efficacy across doses and the influence of demographic factors for personalized medicine remain understudied. This study aimed to: (1) compare the efficacy of different botulinum toxin type B doses using Bayesian methods, (2) evaluate demographic and clinical factors affecting treatment response, and (3) establish a probabilistic framework for personalized cervical dystonia management. We analyzed data from a multicenter randomized controlled trial involving 109 patients assigned to placebo, 5,000 units, or 10,000 units of botulinum toxin type B groups. The primary outcome was the Toronto Western Spasmodic Torticollis Rating Scale measured over 16 weeks. Bayesian hierarchical modeling assessed treatment effects while accounting for patient heterogeneity. Lower botulinum toxin type B doses (5,000 units) showed greater overall Toronto Western Spasmodic Torticollis Rating Scale score reductions (treatment effect: -2.39, 95% Probability Interval: -4.10 to -0.70). Male patients demonstrated better responses (5.2% greater improvement) than female patients. Substantial between-patient variability and site-specific effects were observed, highlighting the need for personalized protocols. The study confirms botulinum toxin type B's dose-dependent efficacy while identifying key modifiable factors in treatment response. Bayesian methods provided nuanced insights into uncertainty and heterogeneity, paving the way for personalized medicine in cervical dystonia management. |
| title | Bayesian Hierarchical Methods for Surveillance of Cervical Dystonia Treatments |
| topic | Applications |
| url | https://arxiv.org/abs/2508.15762 |