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Main Authors: Salim, Md Shahidul, Fu, Lian, Ramakrishnan, Arav Adikesh, Yao, Zonghai, Yu, Hong
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2509.00934
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author Salim, Md Shahidul
Fu, Lian
Ramakrishnan, Arav Adikesh
Yao, Zonghai
Yu, Hong
author_facet Salim, Md Shahidul
Fu, Lian
Ramakrishnan, Arav Adikesh
Yao, Zonghai
Yu, Hong
contents We present MedCOD (Medical Chain-of-Dictionary), a hybrid framework designed to improve English-to-Spanish medical translation by integrating domain-specific structured knowledge into large language models (LLMs). MedCOD integrates domain-specific knowledge from both the Unified Medical Language System (UMLS) and the LLM-as-Knowledge-Base (LLM-KB) paradigm to enhance structured prompting and fine-tuning. We constructed a parallel corpus of 2,999 English-Spanish MedlinePlus articles and a 100-sentence test set annotated with structured medical contexts. Four open-source LLMs (Phi-4, Qwen2.5-14B, Qwen2.5-7B, and LLaMA-3.1-8B) were evaluated using structured prompts that incorporated multilingual variants, medical synonyms, and UMLS-derived definitions, combined with LoRA-based fine-tuning. Experimental results demonstrate that MedCOD significantly improves translation quality across all models. For example, Phi-4 with MedCOD and fine-tuning achieved BLEU 44.23, chrF++ 28.91, and COMET 0.863, surpassing strong baseline models like GPT-4o and GPT-4o-mini. Ablation studies confirm that both MedCOD prompting and model adaptation independently contribute to performance gains, with their combination yielding the highest improvements. These findings highlight the potential of structured knowledge integration to enhance LLMs for medical translation tasks.
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institution arXiv
publishDate 2025
record_format arxiv
spellingShingle MedCOD: Enhancing English-to-Spanish Medical Translation of Large Language Models Using Enriched Chain-of-Dictionary Framework
Salim, Md Shahidul
Fu, Lian
Ramakrishnan, Arav Adikesh
Yao, Zonghai
Yu, Hong
Computation and Language
Artificial Intelligence
We present MedCOD (Medical Chain-of-Dictionary), a hybrid framework designed to improve English-to-Spanish medical translation by integrating domain-specific structured knowledge into large language models (LLMs). MedCOD integrates domain-specific knowledge from both the Unified Medical Language System (UMLS) and the LLM-as-Knowledge-Base (LLM-KB) paradigm to enhance structured prompting and fine-tuning. We constructed a parallel corpus of 2,999 English-Spanish MedlinePlus articles and a 100-sentence test set annotated with structured medical contexts. Four open-source LLMs (Phi-4, Qwen2.5-14B, Qwen2.5-7B, and LLaMA-3.1-8B) were evaluated using structured prompts that incorporated multilingual variants, medical synonyms, and UMLS-derived definitions, combined with LoRA-based fine-tuning. Experimental results demonstrate that MedCOD significantly improves translation quality across all models. For example, Phi-4 with MedCOD and fine-tuning achieved BLEU 44.23, chrF++ 28.91, and COMET 0.863, surpassing strong baseline models like GPT-4o and GPT-4o-mini. Ablation studies confirm that both MedCOD prompting and model adaptation independently contribute to performance gains, with their combination yielding the highest improvements. These findings highlight the potential of structured knowledge integration to enhance LLMs for medical translation tasks.
title MedCOD: Enhancing English-to-Spanish Medical Translation of Large Language Models Using Enriched Chain-of-Dictionary Framework
topic Computation and Language
Artificial Intelligence
url https://arxiv.org/abs/2509.00934